Paul T Akins

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BACKGROUND Influenza virus infection of the respiratory tract is associated with a range of neurologic complications. The emergence of 2009 pandemic influenza A (H1N1) virus has been linked to neurological complications, including encephalopathy and encephalitis. METHODS Case report and literature review. RESULTS We reviewed case management of a 20-year(More)
BACKGROUND Cerebral ischemia is a potent modulator of gene expression. Immediate early genes undergo rapid induction after both global and focal cerebral ischemia. Many immediate early genes code for transcription factors. Additional genes, including those encoding for neurotrophic factors and neurotransmitter systems, are induced in a delayed fashion after(More)
BACKGROUND Thrombus within the carotid artery usually occurs in vessels with severe atherosclerotic disease and may embolize to cause transient ischemic attacks and cerebral infarctions. The risk factors for carotid artery thrombus formation in the absence of atherosclerosis are not well characterized. A case series is presented that suggests an association(More)
Decompressive craniectomy is reclaiming a role in neurocritical care. The altered pathophysiology found in a cranium converted from a 'closed' box to an 'open' box' carries benefits and risks. In some craniectomy patients, the forces of atmospheric pressure and gravity overwhelm intracranial pressures, and the brain appears sunken. This can lead to(More)
BACKGROUND AND PURPOSE We sought to determine predictors of acute hospital costs in patients presenting with acute ischemic stroke to an academic center using a stroke management team to coordinate care. METHODS Demographic and clinical data were prospectively collected on 191 patients consecutively admitted with acute ischemic stroke. Patients were(More)
BACKGROUND AND PURPOSE Patients with nonvalvular atrial fibrillation and prior stroke or transient ischemic attack (TIA) are at high risk for recurrent stroke. We investigated whether ximelagatran was noninferior to warfarin in patients with prior stroke or TIA. METHODS We analyzed pooled data from the SPORTIF III and V trials in patients with prior(More)
PURPOSE To identify factors that predict survival and good neurologic outcome in patients undergoing basilar artery thrombolysis. METHODS Over a 42-month period, 20 of 22 consecutive patients with angiographic proof of basilar artery thrombosis were treated with local intraarterial urokinase. Brain CT scans, neurologic examinations, symptom duration, clot(More)
BACKGROUND AND PURPOSE This study was undertaken to examine the relationship between collateral flow and outcome after local intraarterial thrombolytic treatment for basilar artery thrombosis. METHODS Twenty-four patients with symptomatic basilar thrombosis were treated with intraarterial urokinase. Angiograms at the time of treatment were analyzed to(More)
BACKGROUND AND PURPOSE Treatment of patients with ischemic stroke after endovascular treatment requires in-depth knowledge of complications. The goal of this study was to make endovascular treatment for acute ischemic stroke safer through an in-depth review of the major periprocedural complications observed in the Solitaire FR With Intention for(More)
Using the whole-cell patch-clamp technique on acutely dissociated and cultured adult rat sensory neurons, we characterized the K+ currents by voltage dependence, kinetics, calcium dependence, and pharmacology. In the presence of Ca channel blockers, the cells heterogeneously expressed transient and sustained outward K+ currents. The transient current was a(More)