It is now clear that airway inflammatory processes characterized by eosinophils and Th2 lymphocytes are pivotal as the pathological features of asthma. Standard inhaled corticosteroids markedly suppress such inflammatory changes, resulting in clinical beneficial effects. However, it is also notified that airway wall remodeling including goblet cell… (More)
Anti-platelet treatment is a key therapeutic intervention in patients with cerebrovascular diseases. However, there is no information on its impact on the release of Brain-derived neurotrophic factor (BDNF), which is stored in large amounts in human platelets and essential for neuronal protection and repair. Here, we show that a single oral dose of… (More)
BACKGROUND Myeloid dendritic cells (DCs) are increased in the airway wall of patients with chronic obstructive pulmonary disease (COPD), and postulated to play a crucial role in COPD. However, DC phenotypes in COPD are poorly understood. METHODS Function-associated surface molecules on bronchoalveolar lavage fluid (BALF) DCs were analyzed using flow… (More)
BACKGROUND Myeloid Dendritic cells are key drivers of inflammation in smoke-related lung diseases, whereas plasmacytoid DCs play a crucial role in the defense against infections. Effects of inhaled corticosteroids (ICS) on airway DCs in smokers are unknown. METHODS In this randomized, double-blind, placebo-controlled clinical trial, 45 active cigarette… (More)
BACKGROUND Dendritic cells (DCs) control immunity and play a role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the expression of function-associated surface molecules on circulating DCs in COPD is unknown. METHODS Four-colour flow cytometry was used to compare blood DC surface molecules of 54 patients with COPD (median… (More)
We report the case of a nosocomial infection due to Enterococcus cecorum isolated from a blood culture of a 75-year-old septic male patient. Matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS) and Vitek 2 succeeded in identification of the isolate.
BACKGROUND Chronic Obstructive Pulmonary Disease (COPD) is characterised by complex inflammatory, neuronal and fibrotic changes. Brain-derived Neurotrophic Factor (BDNF) is a key regulator of neuronal plasticity, whereas Transforming Growth Factor-β1 (TGF-β1) plays a crucial role in tissue repair and emphysema pathogenesis. Both mediators are stored in… (More)