I n the last three decades, several concepts have been advanced to structure efforts to improve policing. Among them have been team policing, neighborhood policing, community policing, problem-oriented policing, and, most recently, quality-of-life policing. With much overlap, each concept, as reflected in its name, emphasizes a different need, relegating… (More)
Design patterns help to improve communication software quality since they address a fundamental challenge in large-scale software development: communication of architectural knowledge among developers. This paper makes several contributions to the study and practice of design patterns. It presents a case study that illustrates how design patterns helped to… (More)
Developing distributed applications that utilize multi-processing and network services is a promising technique for increasing system performance, scalability, and cost effectiveness. However, designing and implementing efficient, robust, and extensible multi-threaded client/server applications is a complex and challenging task. The Service Configurator… (More)
Building system software that is reusable across OS platforms presents developers with many challenges. It is often difficult to reuse existing interfaces and implementations directly due to portability, functionality, and efficiency constraints imposed by different platforms and applications. It may still be possible, however, to leverage prior development… (More)
An earlier version of the paper appeared in the March/April 1995 issue of the C++ Report magazine.
BACKGROUND This phase I, dose-finding study determined the maximum tolerated dose (MTD), safety, and pharmacokinetics of sunitinib plus gemcitabine in patients with advanced solid tumours. METHODS Two schedules with sunitinib (25-50 mg per day) and IV gemcitabine (750-1250 mg m(-2)) in escalating doses were studied. First, patients received sunitinib on a… (More)
SUMMARY: Wireless technology is already available and used in several industrial sectors. In the next few years it is envisaged that the technology will mature and converge with other technologies providing the ability to communicate and exchange data and information easily and effectively anytime, anywhere, and in any place. Alongside this, security… (More)