Paul Stephenson

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OBJECTIVE To compare the prevalence of glucose intolerance (impaired glucose tolerance and diabetes), and its relationship to body mass index (BMI) and waist-hip ratio in Chinese and Europid adults. DESIGN This was a cross sectional study. SETTING Newcastle upon Tyne. SUBJECTS These comprised Chinese and Europid men and women, aged 25-64 years, and(More)
Design patterns help to improve communication software quality since they address a fundamental challenge in largescale software development: communication of architectural knowledge among developers. This paper makes several contributions to the study and practice of design patterns. It presents a case study that illustrates how design patterns helped to(More)
This paper describes the design and implementation of an interface to corpora in 12 languages, stemming from the analysis of the needs of a diverse group of users: language teachers and language students, (non-computational) linguists, researchers in history and translation studies. We identified a set of requirements shared across the disciplines, as well(More)
OBJECTIVE To determine whether non-mydriatic Polaroid retinal photography was comparable to ophthalmoscopy with mydriasis in routine clinic screening for early, treatable diabetic retinopathy. DESIGN Prospective study of ophthalmoscopic findings according to retinal camera screening and ophthalmoscopy and outcome of referral to ophthalmologist. SETTING(More)
The 2008 BTS/SIGN British Guideline on the management of asthma provides comprehensive updated evidence-based guidance on asthma management for healthcare professionals. This primary care-focussed summary has been produced to aid dissemination and implementation of the key guideline messages into primary care. The section on diagnosis emphasises the new(More)
INTRODUCTION The Eastern Region Confidential Enquiry into asthma deaths started in 2001. It incorporates the Norwich and East Anglian Enquiries started in 1988 and 1992, respectively. The aim of this study was to analyse all asthma deaths in the Eastern region between 2001 and 2003, to elicit any factors contributing to the patients' deaths, and to make(More)
Preclinical compounds tested in animal models often show limited efficacy when transitioned into human clinical trials. As a result, many patients are stratified into treatment regimens that have little impact on their disease. In order to create preclinical models that can more accurately predict tumor responses, we established patient-derived xenograft(More)