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  • Valérie Lallemand-Breitenbach, Jun Zhu, +8 authors Hugues de Thé
  • Medicine, Biology
  • The Journal of experimental medicine
  • 2001 (First Publication: 18 June 2001)
  • Promyelocytic leukemia (PML) is the organizer of nuclear matrix domains, PML nuclear bodies (NBs), with a proposed role in apoptosis control. In acute promyelocytic leukemia, PML/retinoic acidContinue Reading
  • Michael N Boddy, Kathy M Howe, L. D. Etkin, E. Solomon, Paul S. Freemont
  • Biology, Medicine
  • Oncogene
  • 1996 (First Publication: 5 September 1996)
  • Acute promyelocytic leukaemia (APL) arises following a reciprocal translocation t(15;17) that fuses PML with retinoic acid receptor alpha (RARA). The PML-RARA fusion protein targets and disruptsContinue Reading
  • Ingrid Dreveny, Hisao Kondo, Keiji Uchiyama, Anthony A. Shaw, Xiaodong Zhang, Paul S. Freemont
  • Biology, Medicine
  • The EMBO journal
  • 2004 (First Publication: 10 March 2004)
  • The AAA ATPase p97/VCP is involved in many cellular events including ubiquitin-dependent processes and membrane fusion. In the latter, the p97 adaptor protein p47 is of central importance. In orderContinue Reading