Paul S. Jacobs

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PHRED (PHRasal English Diction is a natural language generator designed for use in a variety of domains. It was constructed to share a knowledge base with PHRAN (PHRasal ANalyzer) as part of a real-time user-friendly interface. The knowledge base consists of pattern-concept pairs, i.e., associations between linguistic structures and conceptual templates.(More)
To understand the roles of secretory peptides in developmental signaling, we have studied Drosophila mutant for the gene peptidylglycine alpha-hydroxylating monooxygenase (PHM). PHM is the rate-limiting enzyme for C-terminal alpha-amidation, a specific and necessary modification of secretory peptides. In insects, more than 90% of known or predicted(More)
Intracerebroventricular (i.c.v.) administration of kainic acid (KA) to rats produces neuronal loss in the hippocampus and other areas of the limbic system. The present study demonstrates that i.c.v. KA enhances the locomotor response to novelty and saline injection, as well as to amphetamine and MK-801. Sixteen to 18 days after i.c.v. administration of KA(More)
Automatic news categorization systems have produced high accuracy, consistency, and flexibility using some natural language processing techniques. These knowledge-based categorization methods are more powerful and accurate than statistical techniques. However, the phrasal pre-processing and pattern matching methods that seem to work for categorization have(More)
Antagonists at the N-methyl-D-aspartate (NMDA)-type glutamate receptor, such as phencyclidine (PCP) and dizocilpine (MK-801), are well-known to evoke increases in locomotor activity in adult rats and mice. However, little is known about the effects of NMDA antagonists on locomotor activity as a function of development. The present study examined locomotor(More)
To learn about construction of the adult nervous system, we studied the differentiation of imaginal neurons in the Drosophila visual system. OL2-A and OL3 are tangential neurons that display dFMRFa neuropeptide gene expression in adults but not in larvae. The two large OL2-A neurons are generated near the end of the embryonic period and already show(More)