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A problem frame is a generic, abstract description of the structure of a problem. Using a problem frame requires selecting a candidate frame from a catalog and mapping the specific parts of the problem into the principal parts of the frame. In this paper we present five patterns, one for each of Jackson's original problem frames. We hope that by writing(More)
High dose intravenous(i.v.) ascorbic acid (AA) has been used as therapy for infectious disease from bacterial and viral origin and adjuvant therapy for cancer. In this publication we describe a clinical protocol that has been developed over the past twenty years utilizing high dose i.v. AA as therapy for cancer. This includes principles of treatment,(More)
Case studies suggest that vitamin C, given intravenously at doses of 10-100 grams/day can improve patient well being and in some cases, reduce tumor size. While ascorbate is generally considered safe, clinical data on high intravenous doses is limited. Twenty-four late stage terminal cancer patients were given continuous infusions of 150 to 710 mg/kg/day(More)
An inflammatory component is present in the microenvironment of most neoplastic tissues. Inflammation and elevated C-reactive protein (CRP) are associated with poor prognosis and decreased survival in many types of cancer. Vitamin C has been suggested as having both a preventative and therapeutic role in a number of pathologies when administered at much(More)
The epigenetic pathway of a cell as it differentiates from a stem cell state to a mature lineage-committed one has been historically understood in terms of Waddington's landscape, consisting of hills and valleys. The smooth top and valley-strewn bottom of the hill represent their undifferentiated and differentiated states, respectively. Although(More)
It has long been understood there is a link between a nutrient deficiency and visually measurable health. In separate studies, Sprague Dawley or Fischer 344 rats were fed diets lacking 100% of one B vitamin until a single mortality occurred. Vitamins studied were thiamin, riboflavin, niacin, pyridoxine, pantothenic acid, cobalamin and folate. Body mass,(More)