Paul R. Taylor

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High dose intravenous(i.v.) ascorbic acid (AA) has been used as therapy for infectious disease from bacterial and viral origin and adjuvant therapy for cancer. In this publication we describe a clinical protocol that has been developed over the past twenty years utilizing high dose i.v. AA as therapy for cancer. This includes principles of treatment,(More)
A problem frame is a generic, abstract description of the structure of a problem. Using a problem frame requires selecting a candidate frame from a catalog and mapping the specific parts of the problem into the principal parts of the frame. In this paper we present five patterns, one for each of Jackson's original problem frames. We hope that by writing(More)
Case studies suggest that vitamin C, given intravenously at doses of 10-100 grams/day can improve patient well being and in some cases, reduce tumor size. While ascorbate is generally considered safe, clinical data on high intravenous doses is limited. Twenty-four late stage terminal cancer patients were given continuous infusions of 150 to 710 mg/kg/day(More)
TO THE EDITOR: Research has shown that intravenous, but not oral ascorbate, can produce concentrations selectively toxic to cancer cells, which has renewed the interest in ascorbate as therapy for cancer.1,2 The protocol was approved by the ethics committee of The Center for Improvement of Human Functioning, Wichita, KS. Written informed consent was(More)
The epigenetic pathway of a cell as it differentiates from a stem cell state to a mature lineage-committed one has been historically understood in terms of Waddington's landscape, consisting of hills and valleys. The smooth top and valley-strewn bottom of the hill represent their undifferentiated and differentiated states, respectively. Although(More)
The discovery of useful applications of agent technology is currently generating considerable interest in both research and business domains. The term ‘agent technology’ refers to a bag of software technologies and methods that realise systems comprised of multiple autonomous, goal-seeking agents that employ cooperation and collaboration to automate or(More)
Patterns have recognised utility in software engineering design and development processes. The body of knowledge of design and development of agent-based systems is now sufficiently mature to be usefully expressed as a pattern language. The essential elements of agent-based decomposition - autonomous agents, relationships between agents, and organisational(More)
This paper attempts distillation of the essential design themes of Frank Lloyd Wright’s prairie houses in pattern form. The result is a pattern language fragment that documents the key features of Wright’s architectural style and an interpretation of Wright’s design justifications and motivations. The exercise serves to illustrate the use of patterns and(More)