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STUDY DESIGN Review of the literature. OBJECTIVES Review the definition, etiology, incidence, and risk factors associated with as well as potential treatment options. SUMMARY OF BACKGROUND DATA The development of pathology at the mobile segment next to a lumbar or lumbosacral spinal fusion has been termed adjacent segment disease. Initially reported to(More)
High aldehyde dehydrogenase (ALDH) activity has recently been used to identify tumorigenic cell fractions in many cancer types. Herein we hypothesized that a subpopulation of cells with cancer stem cells (CSCs) properties could be identified in established human osteosarcoma cell lines based on high ALDH activity. We previously showed that a subpopulation(More)
Calcifying pseudoneoplasms have been rarely reported to involve the spine. Diagnostically, MRI characteristics have not been well-described. We present the case of a 59-year-old woman with a C8 radiculopathy and history significant for metastatic breast cancer. MRI showed a C7-T1 extradural mass with an isointense signal to the spinal cord on T1- and(More)
STUDY DESIGN Retrospective clinical series. OBJECTIVE To evaluate the management and outcomes of patients with unilateral, asymptomatic vertebral artery occlusion (VAO) undergoing surgery for cervical fractures associated with subluxation. SUMMARY OF BACKGROUND DATA The management of VAO is controversial with several treatment options available,(More)
OBJECT Minimally invasive (MI) transforaminal lumbar interbody fusion (TLIF) has proven to be effective in the treatment of spondylolisthesis and degenerative disc disease (DDD). Compared with the traditional open TLIF, the MI procedure has been associated with less blood loss, less postoperative pain, and a shorter hospital stay. However, it is uncertain(More)
OBJECT Tethering of the spinal cord has been a recognized cause of neurological symptoms in pediatric patients and is increasingly being recognized as a cause of symptoms in adults as well. The pathophysiology surrounding spinal cord tethering has begun to be understood in the pediatric population but is still unclear in adult patients. METHODS Using a(More)
Bone morphogenetic protein-2 (BMP-2), a member of the transforming growth factor superfamily, has been shown to have inhibitory effect on many tumor types. However, the effect of BMP-2 on human renal cell carcinoma (RCC) is still unknown. We previously showed that BMP-2 inhibits tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cells. Our(More)
OBJECT Stereotactic radiosurgery (SRS) has proven to be a safe and effective treatment for many patients with intracranial meningiomas. Nevertheless, the morbidity associated with radiosurgery of larger meningiomas is poorly understood. METHODS The authors performed a retrospective review of 116 patients who underwent SRS for meningiomas (WHO Grade I) >(More)
OBJECTIVE Open lumbar spinal surgery in overweight or obese patients has been associated with increased risk of perioperative complications. The impact of minimally invasive spinal (MIS) surgery on the incidence of perioperative adverse events in overweight or obese patients, however, has not been well evaluated. METHODS A retrospective review of(More)