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Multi-pulse drug delivery from a resorbable polymeric microchip device
TLDR
Biodegradable polymeric microchips were fabricated that released four pulses of radiolabelled dextran, human growth hormone or heparin in vitro that retained on average 96 ± 12% of its bioactivity.
Local drug delivery to the brain.
Diffuse metabolic abnormalities in reversible posterior leukoencephalopathy syndrome.
TLDR
Widespread metabolic abnormalities, consisting of increased choline and creatine levels and mildly decreased N-acetylaspartate, occurred in regions with both normal and abnormal MR imaging appearances.
Distal ventriculoperitoneal shunt failure caused by silicone allergy. Case report.
TLDR
It is indicated that replacing the original silicone-based shunt system with a polyurethane-based system alone is sufficient in the treatment of a silicone shunt allergy.
Delayed Intracranial Delivery of a Nitric Oxide Donor from a Controlled-release Polymer Prevents Experimental Cerebral Vasospasm in Rabbits
TLDR
Delayed treatment of SAH with controlled-release DETA-NO polymers prevented experimental posthemorrhagic vasospasm in the rabbit, and this inhibition was dose-dependent, which further confirms the role of NO in the pathogenesis of vasospasms.
Inhibition of cerebral vasospasm by intracranial delivery of ibuprofen from a controlled-release polymer in a rabbit model of subarachnoid hemorrhage.
TLDR
Local intracranial delivery of ibuprofen accomplished using controlled-release polymers prevents vasospasm in the rabbit BA model of vasospasms when administered within 6 hours after blood exposure.
Local Intracerebral Administration of Paclitaxel with the Paclimer® Delivery System: Toxicity Study in a Canine Model
TLDR
Paclimer®-based delivery of paclitaxel is safe for intraparenchymal delivery at the tested doses in normal dogs, and there was no evidence of systemic toxicity or myelosuppression.
Acute Intracranial Subdural Hematoma Following a Lumbar CSF Leak Caused by Spine Surgery
TLDR
The rare case of an acute intracranial subdural hematoma caused by a CSF leak following lumbar surgery is reported to illustrate the potential morbidity associated with CSF leaks occurring after spinal surgery.
Characteristics and Reversibility of Dementia in Normal Pressure Hydrocephalus
TLDR
Testing before and after temporary drainage may be useful in predicting which patients are less likely to improve in memory with shunting, as well as predicting which cognitive functions improve with shunt insertion.
Ultrasound guidance for distal insertion of ventriculo-atrial shunt catheters: technical note
TLDR
A method for atrial catheter placement using ultrasound guidance to visualize the IJV and facilitate percutaneous venous puncture in 17 adult patients undergoing treatment for hydrocephalus or pseudotumor cerebri is described.
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