Paul O'Brien

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BACKGROUND We attempted to compare the safety and efficacy of laparoscopic adjustable gastric banding with vertical-banded gastroplasty and gastric bypass. Morbid obesity presents a serious health issue for Western countries, with a rising incidence and a strong association with increased mortality and serious comorbidities, such as diabetes,(More)
Recently, two studies have reported an association between the alpha2-macroglobulin gene on chromosome 12 and late-onset Alzheimer's disease, whereas others have not been able to replicate these findings. By using a prospective population-based study, we have investigated the relation between two polymorphisms in this gene with the presence of the disease(More)
BACKGROUND Axillary lymph node status in breast cancer patients remains the single most important predictor of outcomes. Current methods of histopathologic analysis may be inadequate because 30% of node-negative patients recur. The purpose of this study was to test the hypothesis that a multigene reverse transcriptase-polymerase chain reaction (RT-PCR)(More)
The microvasculature of the rat forestomach was compared with that of the glandular stomach using scanning electron microscopy of vascular corrosion casts and conventional transmission electron microscopy. The forestomach stratified mucosa is relatively poorly vascularized, having a simple 2 dimensional array of continuous capillaries located(More)
Solvent/detergent (S/D) plasma is being increasingly widely used in clinical practice, as it carries significantly lower risk of lipid-enveloped viral transmission than standard fresh frozen plasma (FFP). However, previous reports have suggested that S/D processing might influence the coagulation factor content of plasma. We have investigated this question(More)
pH measurements were recorded from the mucosal surfaces of the rat forestomach and glandular stomach following stimulation of acid-secretion by pentagastrin. Animals containing a normal gastric bolus showed lower forestomach acidity (pH 4.3, cf. 3.2) as did coprophagic animals that contained a fecal gastric bolus (pH 6.0, cf. 3.6). Animals without a gastric(More)
The behavior and treatment of gastrointestinal carcinoid tumors have been the subject of much discussion. Size, location, and histologic invasiveness have been shown to correlate with regional and remote metastasis in previous series. We reviewed 81 patients with gastrointestinal carcinoids seen at the Medical University of South Carolina Teaching Hospitals(More)
The adjuvant treatment of high-risk malignant melanoma remains problematic. Previously we reported moderate success in the treatment of metastatic disease using tamoxifen, cisplatin, dacarbazine and carmustine. Based upon data that suggested tamoxifen and cisplatin were the active agents in this regimen, we initiated a phase II trial of this combination in(More)