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SIR—The recent British Women's Heart and Health Study regarding orthostatic hypotension (OH) and medications suggests that clinicians should be cautious in the context of older adults taking antihypertensives and that OH is a 'major reason for withdrawal of antihypertensives' [1]. The corresponding editorial queries whether our treating BP in the elderly(More)
Rats were taught to select eight holes in a 4 x 4 holeboard for food reinforcements. Upon reaching criterion, they were given subtotal lesions of the anterior hippocampus or sham operations. They then received either the calcium channel blocker, nimodipine, or vehicle alone. Retention testing revealed a significant main effect of lesion and evidence for(More)
BACKGROUND Recruitment to randomised prevention trials is challenging, not least for intracerebral haemorrhage (ICH) associated with antithrombotic drug use. We investigated reasons for not recruiting apparently eligible patients at hospital sites that keep screening logs in the ongoing REstart or STop Antithrombotics Randomised Trial (RESTART), which seeks(More)
OBJECTIVE To investigate whether the location and extent of the CT hyperdense artery sign (HAS) at presentation affects response to IV alteplase in the randomized controlled Third International Stroke Trial (IST-3). METHODS All prerandomization and follow-up (24-48 hours) CT brain scans in IST-3 were assessed for HAS presence, location, and extent by(More)
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