Learn More
A key challenge of functional genomics today is to generate well-annotated data sets that can be interpreted across different platforms and technologies. Large-scale functional genomics data often fail to connect to standard experimental approaches of gene characterization in individual laboratories. Furthermore, a lack of universal annotation standards for(More)
1. Ribozymes can be designed to cleave in trans, i.e. several substrate molecules can be turned over by one molecule of the catalytic RNA. Only small molecular weight ribozymes, or small ribozymes, are discussed in this review with particular emphasis on the hammerhead ribozyme as this has been most widely used for the inhibition of gene expression by(More)
BACKGROUND Providing health care services in Africa is hampered by severe scarcity of personnel, medical supplies and financial funds. Consequently, managers of health care institutions are called to measure and improve the efficiency of their facilities in order to provide the best possible services with their resources. However, very little is known about(More)
Societal cost-of-illness in a German sample of patients with borderline personality disorder (BPD) was calculated for 12 months prior to an outpatient Dialectical Behavior Therapy (DBT) program, during a year of DBT in routine outpatient care and during a follow-up year. We retrospectively assessed resource consumption and productivity loss by means of a(More)
In the context of the joint project GANI_MED (Greifswald Approach to Individualized Medicine) certain disease phenotypes and biomarker candidates are to be identified with the help of association studies. Thus, GANI_MED aims at contributing to the establishment of routines, improving the implementation of PPPM in the clinical area. A unique characteristic(More)
  • Friedrich Breyer, Volker Konstanz, Ulrich, Greifswald, Zusammenfassung Die, bullet Für +9 others
  • 2016
It is the purpose of this study to forecast the future development of total expenditures of sickness funds in Germany under the assumption that present institutions remain unchanged. Previous approaches using present age-specific expenditure data are systematically flawed. In contrast, we use regression analysis to isolate the factors responsible for the(More)
The aim of our research was to collect comprehensive data about the public and physician awareness, acceptance and use of Personalized Medicine (PM), as well as their opinions on PM reimbursement and genetic privacy protection in the U.S. and Germany. In order to give a better overview, we compared our survey results with the results from other studies and(More)
BACKGROUND The cost of dialysis in low and middle-Income countries has not been systematically reviewed. The objective of this article is to systematically review peer-reviewed articles on the cost of dialysis across low and middle-income countries. METHODS PubMed and Embase databases were searched for the year 1998 to March 2013, and additional studies(More)
OBJECTIVES The study objective was to identify the size of different hospital financing sources for different hospital services and their impact on the uninsured. METHODS A panel dataset of 84 public general hospitals (2005-2008) with cross-section data on hospital activity and hospital revenue was created and used to calculate unit costs of different(More)
A key challenge of functional genomics today is to generate well-annotated data sets that can be interpreted across different platforms and technologies. Large-scale functional genomics data often fail to connect to standard experimental approaches of gene characterization in individual laboratories. Furthermore, a lack of universal annotation standards for(More)
  • 1