Paul M. Anderson

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Maps of upper-level and surface winds and of surface temperature and precipitation illustrate the results of a sequence of global paleoclimatic simulations spanning the past 21,000 years for North America. We review a) the large-scale features of circulation, temperature, and precipitation that appear in the simulations from the NCAR Community Climate Model(More)
The ornithine–urea cycle (OUC) is present in elasmobranch fish and many terrestrial vertebrates. Recently, a functional OUC has been reported in a few teleost species, suggesting that all teleost fish have the genes for the OUC, but expression is relatively rare. We investigated the possibility that the OUC is expressed during early development in trout as(More)
Volatile compounds were collected from apple branches (Malus domestica) at different developmental stages, and the antennal response of codling moth females (Cydia pomonella) to these compounds was recorded by electroantennography coupled to gas chromatography. Presence of a range of terpenoid compounds, many of which had antennal activity, was(More)
Knockout (KO) mice lacking steroidogenic factor 1 (SF-1) exhibit a phenotype that includes adrenal and gonadal agenesis, impaired gonadotropin expression, and abnormalities of the ventromedial hypothalamic nucleus (VMH). Studies in rodents with lesions of the ventromedial hypothalamus have implicated the VMH in body weight regulation, suggesting that SF-1(More)
A single non-anaesthetic dose of ketamine, a non-competitive NMDA receptor (NMDAR) antagonist with hallucinogenic properties, induces cognitive impairment and psychosis, and aggravates schizophrenia symptoms in patients. In conscious rats an equivalent dose of ketamine induces key features of animal models of acute psychosis, including hyperlocomotor(More)
Sensory and cognitive deficits are common in schizophrenia. They are associated with abnormal brain rhythms, including disturbances in γ frequency (30-80 Hz) oscillations (GFO) in cortex-related networks. However, the underlying anatomofunctional mechanisms remain elusive. Clinical and experimental evidence suggests that these deficits result from a(More)
Transmission line protective systems are sometimes very complex, incorporating many different equipment groups, often at widely separated places, and often requiring high-speed communications for proper operation. The inherent reliability of such complex systems is a concern of the protection engineer and presents a significant analytical problem. This(More)
Cytidine triphosphate synthetases (CTPSs) produce CTP from UTP and glutamine, and regulate intracellular CTP levels through interactions with the four ribonucleotide triphosphates. We solved the 2.3-A resolution crystal structure of Escherichia coli CTPS using Hg-MAD phasing. The structure reveals a nearly symmetric 222 tetramer, in which each bifunctional(More)
as metabolic fuel and as precursors for protein, lipid and carbohydrate synthesis (Wood, 1993; Moon and Johnston, 1981; Mommsen and Walsh, 1992). Dietary carbohydrate does not appear to be an important aerobic fuel, although fish have a high capacity for gluconeogenesis from exogenous amino acids (Wood, 1993). In contrast, dietary lipid is important,(More)
BACKGROUND Cyanase is an enzyme found in bacteria and plants that catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. In Escherichia coli, cyanase is induced from the cyn operon in response to extracellular cyanate. The enzyme is functionally active as a homodecamer of 17 kDa subunits, and displays half-site binding of(More)