Paul L. Roebuck

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MOTIVATION High-throughput reverse-phase protein array (RPPA) technology allows for the parallel measurement of protein expression levels in approximately 1000 samples. However, the many steps required in the complex protocol (sample lysate preparation, slide printing, hybridization, washing and amplified detection) may create substantial variability in(More)
Description A package to analyze reverse phase protein lysate arrays. 1 2 CobsFitClass-class Index 35 SuperCurve-package Reverse phase protein lysate array analysis Description A package for analyzing reverse phase protein lysate arrays (RPPA). Details For a complete list of functions, use library(help="SuperCurve"). For a high-level summary of the changes(More)
Functional proteomics represents a powerful approach to understand the pathophysiology and therapy of cancer. However, comprehensive cancer proteomic data have been relatively limited. As a part of The Cancer Genome Atlas (TCGA) Project and other efforts, we have generated protein expression data over a large number of tumor and cell line samples using(More)
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