Learn More
RATIONALE High-resolution computed tomography (HRCT) has been suggested as a potential outcome surrogate for cystic fibrosis (CF) lung disease. An important attribute of a valid outcome surrogate is that the surrogate reflects true clinical outcomes. OBJECTIVES We performed this study to validate HRCT, a proposed surrogate outcome measure for CF lung(More)
PURPOSE To estimate the prevalence of abdominal computed tomographic (CT) findings in sarcoidosis and to correlate these findings with those at chest radiography, clinical status, and level of angiotensin converting enzyme (ACE). MATERIALS AND METHODS Abdominal CT examinations in 59 patients with sarcoidosis were evaluated for adenopathy, liver and spleen(More)
OBJECTIVE To assess pulmonary abnormalities detected by high-resolution computed tomography (HRCT) in young children with cystic fibrosis (CF) and mild to moderate lung disease. STUDY DESIGN High-resolution computed tomography was performed in 60 children, 6 to 10 years old, with mild to moderate lung disease (forced expiratory volume in 1 minute(More)
OBJECTIVES To 1) study a variant delayed reaction to tuberculin testing as a way to enhance screening for tuberculosis among high-risk persons and 2) correlate the delayed reaction with lymphocyte blastogenesis. DESIGN Cross-sectional study. SETTING 2 public health department clinics in North Carolina. PARTICIPANTS 121 adults who had recently(More)
BACKGROUND Primary ciliary dyskinesia (PCD) is a recessive genetic disorder that is characterized by sinopulmonary disease and reflects abnormal ciliary structure and function. Situs inversus totalis occurs in approximately 50% of PCD patients (Kartagener's syndrome in PCD), and there are a few reports of PCD with heterotaxy (situs ambiguus), such as(More)
The prevalence of nontuberculous mycobacteria (NTM) is high (approximately 13%) in sputum of patients with cystic fibrosis (CF), but the impact on lung disease is unknown. We followed 60 incident NTM-positive and 99 culture-negative patients with CF for 15 months and assessed clinical impact of NTM by FEV1 and high-resolution computed tomography (HRCT) of(More)
BACKGROUND Outcome surrogates are indicators that reflect, rather than directly measure, patient benefit. In order to provide useful results, however, outcome surrogates must be carefully chosen and must meet specific criteria. OBJECTIVE To support development of high-resolution computed tomography (HRCT) as an outcome surrogate in cystic fibrosis (CF) by(More)
OBJECTIVE High-resolution CT is an important tool in the detection and management of bronchiectasis, but there is little information about high-resolution CT findings in primary ciliary dyskinesia (PCD). We analyzed all high-resolution CT studies of the chest available for a cohort of PCD patients to identify an associated pattern of high-resolution CT(More)
BACKGROUND If lungs could be retrieved from non-heart-beating donors, the critical shortage of lungs for transplant could be alleviated. An obstacle to this approach is the inability to predict these lungs' suitability for transplant. We used human lungs deemed unsuitable for transplant to develop a method to perfuse and ventilate human lungs ex vivo to(More)
Storage-phosphor digital radiographic systems are becoming widely used in a variety of diagnostic procedures. The equipment is reliable and produces images of consistently high quality. However, the images may contain artifacts directly related to the digital techniques used, to the phosphor imaging plate, or to radiography in general. This article(More)