Paul K. Marsden

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Respiratory motion models have potential application for estimating and correcting the effects of motion in a wide range of applications, for example in PET-MR imaging. Given that motion cycles caused by breathing are only approximately repeatable, an important quality of such models is their ability to capture and estimate the intra- and inter-cycle(More)
The relationship between the human brain response to acute stress and subjective, behavioural and physiological responses is poorly understood. We have examined the human cerebral response to the intense interoceptive stressor of hypoglycemia, controlling plasma glucose at either normal fasting concentrations (5 mmol/l, n=7) or at hypoglycemia (2.7 mmol/l,(More)
The aim of this project is to verify the accuracy of positron emission tomography (PET) in identifying the tumour boundary and eventually to enable PET-guided resection with removal of significantly smaller margins. We present a novel use of an image-guided surgery system to enable alignment of preoperative PET images to postoperative histology. The oral(More)
The purpose of the present study was to explore the brain regions involved in human episodic memory by correlating unilateral memory performance estimated by the intracarotid amobarbital test (IAT) and interictal cerebral metabolism measured by [(18)F]fluorodeoxyglucose positron emission tomography ([(18)F]FDG-PET). Using this method, regional alterations(More)
Respiratory motion is a complicating factor in PET imaging as it leads to blurring of the reconstructed images which adversely affects disease diagnosis and staging. Existing motion correction techniques are often based on 1D navigators which cannot capture the inter- and intra-cycle variabilities that may occur in respiration. MR imaging is an attractive(More)
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