Paul JR Barton

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Left ventricular mass (LVM) is a highly heritable trait and an independent risk factor for all-cause mortality. So far, genome-wide association studies have not identified the genetic factors that underlie LVM variation, and the regulatory mechanisms for blood-pressure-independent cardiac hypertrophy remain poorly understood. Unbiased systems genetics(More)
INTRODUCTION Idiopathic dilated cardiomyopathy (DCM) is a leading cause of heart failure characterized by an enlarged ventricular cavity leading to systolic dysfunction. DCM patients have a considerable annual mortality rate of 5–10%, with half of them being sudden unexpected deaths due to ventricular tachycardia (VT) or ventricular fibrillation (VF). 1(More)
Ideally during the course of a fermentation, an on-line measure estimating the performance of the current operation is desired. It is beneficial to determine as soon as possible whether the current run is of acceptable quality. Unfortunately, due to the poor mechanistic understanding of most biological systems complicated further by the lack of appropriate(More)
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