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New cell lines from mouse epiblast share defining features with human embryonic stem cells
The application of human embryonic stem (ES) cells in medicine and biology has an inherent reliance on understanding the starting cell population. Human ES cells differ from mouse ES cells and theExpand
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Derivation of naïve human embryonic stem cells
Significance We report on generation of nontransgenic, naïve human pluripotent cells that represent the developmentally earliest state described for human established cells. Existing human ES cellExpand
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Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions.
Epigenetic regulation of gene enhancer elements is important for establishing and maintaining the identity of cells. Gene enhancer elements are thought to exist in either active or poised statesExpand
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Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo
Multiple sclerosis involves an aberrant autoimmune response and progressive failure of remyelination in the central nervous system. Prevention of neural degeneration and subsequent disabilityExpand
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Transcription factor–mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells
Cell-based therapies for myelin disorders, such as multiple sclerosis and leukodystrophies, require technologies to generate functional oligodendrocyte progenitor cells. Here we describe directExpand
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Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency.
Naive mouse embryonic stem cells (mESCs) and primed epiblast stem cells (mEpiSCs) represent successive snapshots of pluripotency during embryogenesis. Using transcriptomic and epigenomic mapping weExpand
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Epigenomic Enhancer Profiling Defines a Signature of Colon Cancer
Colorectal Cancer Signature The mutations and genome aberrations that characterize cancer result in often dramatically altered gene and protein expression patterns. It is these altered expressionExpand
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Isolation of epiblast stem cells from preimplantation mouse embryos.
Pluripotent stem cells provide a platform to interrogate control elements that function to generate all cell types of the body. Despite their utility for modeling development and disease, theExpand
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Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells.
Glioblastomas display hierarchies with self-renewing cancer stem-like cells (CSCs). RNA sequencing and enhancer mapping revealed regulatory programs unique to CSCs causing upregulation of the ironExpand
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CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis.
De novo mutation of the gene encoding chromodomain helicase DNA-binding protein 7 (CHD7) is the primary cause of CHARGE syndrome, a complex developmental disorder characterized by the co-occurrenceExpand
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