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HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter.

• Alice Kiselyuk, Seung-Hee Lee, +21 authors Fred Levine
• Chemistry & biology
• 2012

Hepatocyte nuclear factor (HNF)4α is a central regulator of gene expression in cell types that play a critical role in metabolic homeostasis, including hepatocytes, enterocytes, and pancreatic β… (More)

Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C.

• Martin Villalba, Kun Bi, +7 authors Amnon Altman
• The Journal of cell biology
• 2002

PKCtheta plays an essential role in activation of mature T cells via stimulation of AP-1 and NF-kappaB, and is known to selectively translocate to the immunological synapse in antigen-stimulated T… (More)

Epicardial FSTL1 reconstitution regenerates the adult mammalian heart.

• Ke Wei, Vahid Serpooshan, +24 authors Pilar Ruiz-Lozano
• Nature
• 2015

The elucidation of factors that activate the regeneration of the adult mammalian heart is of major scientific and therapeutic importance. Here we found that epicardial cells contain a potent… (More)

Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD.

• Martin Villalba, Paul J. Bushway, Amnon Altman
• Journal of immunology
• 2001

Protein kinase C (PKC)-activating phorbol esters protect T cells from Fas-induced apoptosis. However, the mechanism of this protective effect and the identity of the relevant PKC isoform(s) are… (More)

SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells.

• Yoshihiko Tanaka, Kun Bi, +7 authors Amnon Altman
• Immunity
• 2003

We describe the isolation of a protein, SWAP-70-like adapter of T cells (SLAT), which is expressed at high levels in thymocytes and differentiated Th2 cells. SLAT expression was upregulated in… (More)

Natural and Synthetic Regulators of Embryonic Stem Cell Cardiogenesis

• Erik Willems, Paul J. Bushway, Mark Mercola
• Pediatric Cardiology
• 2009

Debilitating cardiomyocyte loss underlies the progression to heart failure. Although there have been significant advances in treatment, current therapies are intended to improve or preserve heart… (More)

Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells.

• Erik Willems, Joaquim Cabral-Teixeira, +9 authors Mark Mercola
• Cell stem cell
• 2012

The cellular signals controlling the formation of cardiomyocytes, vascular smooth muscle, and endothelial cells from stem cell-derived mesoderm are poorly understood. To identify these signals, a… (More)

Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K– and Vav-dependent pathway, but does not absolutely require phospholipase C

• Martin Villalba, Kun Bi, +7 authors Amnon Altman
• The Journal of Cell Biology
• 2002

1 Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121 2 Laboratory of Intracellular Signaling and Gene Regulation, Institut de Génétique Moléculaire de… (More)

Id genes are essential for early heart formation.

• Thomas Cunningham, Michael S. Yu, +16 authors Alexandre R. Colas
• Genes & development
• 2017

Deciphering the fundamental mechanisms controlling cardiac specification is critical for our understanding of how heart formation is initiated during embryonic development and for applying stem cell… (More)

Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis.

• Alexandre R. Colas, Wesley L. McKeithan, +5 authors Mark Mercola
• Genes & development
• 2012

Tight control over the segregation of endoderm, mesoderm, and ectoderm is essential for normal embryonic development of all species, yet how neighboring embryonic blastomeres can contribute to… (More)

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