Paul J. Brombacher

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Twenty eight clinical chemical blood parameters were studied with respect to intra-individual variations. Both short term variations, within one day and during one week, and long term variations, during a six months period, were investigated in groups of 62, 16 and 274 individuals. Moreover, critical differences were calculated from the total variations,(More)
Glycosylated haemoglobin (HbA1) and glycosylated serum protein concentrations (fructosamine) were monitored in 162 normal pregnancies. The response to the standard 75 g oral glucose tolerance test (OGTT) was used to exclude gestational diabetes. A significant increase in glucose intolerance, measured from the area under the OGTT-curve (r = 0.29, P less than(More)
The complete blood cell count and the differential leukocyte count have been studied for their variations within-one-day and during one week (short-term variations) and during a period of six months (long-term variations) with an automatic haematology analyser (H-6000, Technicon), in which some new parameters (large unstained cells, high peroxidase cells,(More)
The reagent test strip Combur-9 Test-RL (Boehringer Mannheim) and the 8-SG Multistix (Ames) were simultaneously evaluated as a rapid method for screening urines for normality. Differences between the two methods are for a considerable part determined by adjustment of the lowest detection limits of the leukocyte and erythrocyte dipstick fields. Patient(More)
Unsatisfactory results obtained by histological evaluation of liver tissue in iron loading diseases prompted us to study the distribution of the total liver iron, haem iron and ferritin iron in post mortem human liver tissue from two different sites of the same liver. The total liver iron content was measured by flameless atomic absorption spectroscopy in(More)
We determined serum ferritin, C-reactive protein (CRP), fibrinogen, and the erythrocyte sedimentation rate (ESR) in 73 patients with anemia of chronic disease. Nomograms of CRP, ESR, or fibrinogen vs ferritin concentrations were constructed and used to estimate the iron store in bone marrow. Iron stores estimated from the nomograms were compared with the(More)
Bacterial flora of ileum effluent and bile acid metabolism were investigated in 11 patients 11-44 months after construction of a Kock's continent ileostomy. Bacteriologic investigation showed significantly more microorganisms per millilitre (p less than 0.01) and a more colon-like flora--that is, anaerobic microorganisms (p less than 0.001)--in ileum(More)
The intra-individual variations of 9 coagulation parameters were studied during short-term (within-one-day) and long-term (six months) periods. Two groups of healthy individuals (viz. 60 and 274 persons) were involved. Moreover, critical differences have been calculated from the total variations, comprising both biological and analytical variations. The(More)