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BACKGROUND The process of malignant transformation, progression and metastasis of melanoma is poorly understood. Gene expression profiling of human cancer has allowed for a unique insight into the genes that are involved in these processes. Thus, we have attempted to utilize this approach through the analysis of a series of primary, non-metastatic cutaneous(More)
— This paper describes the design and implementation of a protocol scrubber, a transparent interposition mechanism for explicitly removing network attacks at both the transport and application protocol layers. The transport scrubber supports downstream passive network-based intrusion detection systems; whereas the application scrubbing mechanism supports(More)
MOTIVATION MicroRNA (miRNA) is a set of newly discovered non-coding small RNA molecules. Its significant effects have contributed to a number of critical biological events including cell proliferation, apoptosis development, as well as tumorigenesis. High-dimensional genomic discovery platforms (e.g. microarray) have been employed to evaluate the important(More)
The 14-3-3σ gene promoter is methylated in both human melanocytes and melanoma Abstract Background: Recent evidence demonstrates that 14-3-3σ acts as a tumor suppressor gene inactivated by methylation of its 5' CpG islands in epithelial tumor cells, while remaining un-methylated in normal human epithelia. The methylation analysis of 14-3-3σ has been largely(More)
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