Paul H. Randolph

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The purpose of this study was to evaluate the long-term variability and reproducibility of systolic and diastolic time intervals in human subjects. Ten healthy volunteers underwent serial determinations of systolic and diastolic time intervals and, as internal physiologic standards, heart rate (HR), systemic blood pressures, and resting oxygen consumption(More)
Dose-response infusions (0.25 to 4.0 micrograms/kg/min) and extended infusions of dopexamine, a new synthetic catechol with beta 2 adrenergic and dopaminergic agonist effects, were performed in 12 patients with low output congestive heart failure (CHF). The central and regional hemodynamic effects and responses in renal function were determined and compared(More)
Twenty-one patients with moderately severe congestive heart failure participated in a double-blind, randomized, parallel placebo-controlled trial designed to evaluate the effects of long-term (2 months) indoramin therapy on rest and exercise hemodynamics, exercise capacity and clinical status of patients with this clinical syndrome. The long-term(More)
Tests that are administered over and over, semester after semester will soon become fixtures in various student files and thus will no longer measure achievement but only the cleverness of students in finding files and memorizing answers. By generating examinations in a random fashion by computer, new examinations are easily obtained whenever necessary. APL(More)
One major problem in combinatorial theory is to find a combination that will optimize a given objective function. However, for many real problems even with moderate requirements, no algorithm exists which can find an optimum in a livable span of time. This paper proposes that if the N! combinations are viewed as points in a sample space, then a Monte Carlo(More)
This study was performed to examine the influence of time during the day and of meals on left ventricular performance in patients with dilated cardiomyopathy and chronic congestive heart failure. Systolic time intervals and echocardiography were performed at set intervals with concomitant hemodynamic measurements in nine patients with chronic congestive(More)
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