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Researchers in the field of epigenomics are developing more nuanced understandings of biological complexity, and exploring the multiple pathways that lead to phenotypic expression. The concept of degeneracy-referring to the multiple pathways that a system recruits to achieve functional plasticity-is an important conceptual accompaniment to the growing body(More)
Ageing is a poorly understood process of human development mired by a scientific approach that struggles to piece together distributed variable factors involved in ongoing transformations of living systems. Reconfiguring existing research paradigms, we review the concept of 'degeneracy', which has divergent popular and technical definitions. The technical(More)
India is the country with the highest number of Tuberculosis patients. The current fight against TB in India is characterized by an existing control structure that has been dealing with the disease already for decades. At the same time the 'New Tuberculosis' is emerging due to additional challenges and combined effects of poverty, migration, HIV(More)
Why animal communication displays are so complex and how they have evolved are active foci of research with a long and rich history. Progress towards an evolutionary analysis of signal complexity, however, has been constrained by a lack of hypotheses to explain similarities and/or differences in signalling systems across taxa. To address this, we advocate(More)
OBJECTIVE This opinion piece encourages mental health researchers and clinicians to engage with mental health issues among tuberculosis patients in the Asia-Pacific region in a culturally appropriate and ethical manner. The diversity of cultural contexts and the high burden of tuberculosis throughout the Asia-Pacific presents significant challenges.(More)
The insomnia illness experience can be conceptualised as a form of biographical disruption. Using a critical interpretive phenomenological lens 51 in-depth semi-structured interviews were conducted with patients from specialist sleep and psychology clinics (n = 22) and the general community (n = 29). Patients' narratives revealed key phases of their illness(More)
clinical data including Bangladesh regimen experience support its efficacy [7, 9, 10], and for some patients (as in our case) clofazimine represents the only effective drug, exclusion of clofazimine from salvage therapy would greatly limit treatment efficacy. Patients due to receive a regimen with QT prolonging drugs (i.e. bedaquiline, delamanid,(More)
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