Philippe Corcia4
Pierre-François Pradat3
Patrick Vourc'h2
Caroline Moreau2
Christian R. Andres2
4Philippe Corcia
3Pierre-François Pradat
2Patrick Vourc'h
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  • Hélène Blasco, Philippe Corcia, Caroline Moreau, Ségolène Veau, Clémentine Fournier, Patrick Vourc'h +7 others
  • 2010
BACKGROUND Pathophysiological mechanisms involved in amyotrophic lateral sclerosis (ALS) are complex and none has identified reliable markers useful in routine patient evaluation. The aim of this study was to analyze the CSF of patients with ALS by (1)H NMR (Nuclear Magnetic Resonance) spectroscopy in order to identify biomarkers in the early stages of the(More)
The ability of the pathogenic fungus Candida albicans to switch from a yeast to a hyphal morphology in response to external signals is implicated in its pathogenicity. We used glass DNA microarrays to investigate the transcription profiles of 6333 predicted ORFs in cells undergoing this transition and their responses to changes in temperature and culture(More)
BACKGROUND Mutations in SOD1, ANG, VAPB, TARDBP and FUS genes have been identified in amyotrophic lateral sclerosis (ALS). METHODS The relative contributions of the different mutations to ALS were estimated by systematically screening a cohort of 162 families enrolled in France and 500 controls (1000 chromosomes) using molecular analysis techniques and(More)
  • Yann Nadjar, Paul Gordon, Philippe Corcia, Gilbert Bensimon, Laurence Pieroni, Vincent Meininger +1 other
  • 2012
BACKGROUND Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder caused by the loss of motor neurons. Its etiology remains unknown, but several hypothesis have been raised to explain motor neuron death, including oxidative stress. Dysregulation of cellular iron metabolism can lead to increased oxidative stress, and existing data argue for a(More)
INTRODUCTION The clinical feasibility of noninvasive imaging of interstitial alterations after myocardial infarction (MI) was assessed using a technetium-99m-labeled RGD imaging peptide (RIP). In experimental studies, RIP has been shown to target integrins associated with collagen-producing myofibroblasts (MFB). METHODS AND RESULTS Ten patients underwent(More)
  • Gabrielle Wheway, Miriam Schmidts, Dorus A. Mans, Katarzyna Szymanska, Thanh-Minh T. Nguyen, Hilary Racher +70 others
  • 2015
Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe a whole-genome siRNA-based reverse genetics screen for defects in biogenesis and/or maintenance of the primary cilium, obtaining a global resource. We identify 112 candidate ciliogenesis and ciliopathy genes, including 44 components of the(More)
The purpose of this study was to assess the impact of genetic self-knowledge (nondisease genotype information) on individual self-concept and Health Orientation Scale (HOS). Adult volunteers (n=257) were recruited from an ongoing genetic association study identifying muscle quantitative trait loci (QTLs). Participants completed psychosocial assessments(More)
The pedagogical usage of canons wouldn't seem to be problematic or paradoxical, except in the context of a canon systematizing and categorizing a movement and set of texts that deliberately and inherently positioned themselves against such structures. In examining the relationship between literature and Postmodernism, and texts and readers, the convention(More)
  • Hannah Beckler, Annjeanette Wiese, Paul Gordon, Paul Levitt
  • 2015
This paper addresses the discursive construction of referential truth in Art Spiegelman's Maus and Marjane Satrapi's Persepolis. I argue that referential truth is obtained through the inclusion of both correlative truth and metafictional self-reflection within a nonfictional work. Rather than detracting from their obtainment of referential truth, the comic(More)
In the past fifteen years, the historical study of human rights has seen an exceptional efflorescence. Around the time of the fiftieth anniversary of the 1948 Universal Declaration of Human Rights, the postwar human rights movement, and the apparent transformation it wrought, has been documented and narrated with ever-growing precision and inclusion. (2003)(More)