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We study a neural network consisting of model neurons whose efferent synapses are either excitatory or inhibitory. They are densely interconnected on a local scale, but only sparsely on a larger scale. The local clusters are described by the mean activities of excitatory and inhibitory neurons. The equations for these activities define a neuronal(More)
Development of short-term potentiation (STP) of respiration, which leads to the respiratory 'afterdischarge', was studied in anesthetized, paralyzed, vagotomized and glomectomized cats. Phrenic nerve activity was used as an index of respiratory output. Respiratory output was increased and the potentiating mechanism activated by electrical stimulation of a(More)
We recorded phrenic nerve activity and thalamic single unit firing in unanesthetized, suprathalamically decerebrated, paralyzed and ventilated cats, in which vagi and carotid sinus nerves (CSN) had been ablated. Seventy-six (14%) of 545 neurons in regions of the thalamus related to the ascending reticular system, which had been tonically firing at low(More)
In a previous paper we have shown, that it is possible to model the oscillations observed in an orientation specific column in the visual cortex by coupling excitatory and inhibitory subpopulations of neurons which compose the column, and that these oscillations can be described by the phases of the corresponding limit cycle oscillators. By coupling(More)
1. We recorded phrenic nerve activities and single unit firing of mesencephalic neurones in unanaesthetized supracollicularly decerebrated, paralysed and ventilated cats, in which vagi and carotid sinus nerves had been ablated. We made these measurements first at low levels of respiratory drive associated with normal PCO2 levels, then with increased(More)
The Copyright of this work is owned by the Association for Computational Linguistics (ACL). However, each of the authors and the employers for whom the work was performed reserve all other rights, specifically including the following: ... (4) The right to make copies of the work for internal distribution within the author's organization and for external(More)
The Ether-a-go-go (EAG) superfamily of voltage-gated K(+) channels consists of three functionally distinct gene families (Eag, Elk, and Erg) encoding a diverse set of low-threshold K(+) currents that regulate excitability in neurons and muscle. Previous studies indicate that external acidification inhibits activation of three EAG superfamily K(+) channels,(More)
1. Labeled premotor respiratory neurons from neonatal rats in culture were used to study the effects of (+/-)baclofen, a selective gamma-aminobutyric acid (GABA)b receptor agonist known to inhibit rhythmic breathing movements in mammals. Bath application of (+/-)baclofen-activated outward currents in cell-attached patches, suggesting that a second messenger(More)
We studied the effect of changing drive on resetting of respiratory rhythm in anesthetized cats and in a model (Van der Pol) of a limit-cycle oscillator. In cats, rhythm was perturbed by brief mesencephalic stimuli. Stimulus time in the cycle (old phases) and times of onset of rescheduled breaths (cophases) were measured. Previous study [Paydarfar and(More)