Paul G O'Keefe

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Bitter crab disease (BCD) is caused by Hematodinium sp., an endoparasitic dinoflagellate. It lives within the hemocoeloms of snow crabs Chionoecetes opilio and Tanner crabs C. bairdi, making them unmarketable due to their bitter flavor. Two recent outbreaks of BCD have occurred in Conception Bay, Newfoundland, one from 1999 to 2000 and another from 2003 to(More)
The parasitic dinoflagellate Hematodinium sp. causes a condition known as bitter crab disease (BCD) in snow crabs Chionoecetes opilio and Tanner crabs C. bairdi. As the name of the condition implies, crabs infected with BCD are unmarketable due to their bitter flavor. We surveyed the distribution of BCD in 3 regions within the snow crab fishery of(More)
Hospital-acquired pneumonia was studied prospectively for 3 1/2 years in a 549-bed facility with acute medical-surgical care wards, convalescent wards, and a chronic care unit. Bacteriological studies were limited to transtracheal aspirates, pleural fluid, and blood cultures. The predominant isolates in 159 patients were gram-negative bacilli (47%),(More)
The bacteriology of 21 perimandibular clised-space infections was studied prospectively using optimal bacteriological techniques to collect, transport, and process specimens. There was an average of six microbial species per specimen, including approximately four anaerobes and two aerobes. The predominant aerobes were alpha-hemolytic and non-hemolytic(More)
Blastomyces dermatitidis is responsible for systemic mycoses. It is predominantly caused by inhalation of spores and often manifests as pneumonia, which can potentially disseminate; however, direct cutaneous inoculation may also occur. Blastomycosis in the perigravid period is exceedingly rare. The partial immunosuppressive state induced by pregnancy can(More)
Since the introduction of highly active antiretroviral therapy there has been an improvement in the quality of life for people with HIV infection. Despite the progress made, about 70% of HIV patients develop neurologic complications. These originate either in the central or the peripheral nervous system (Sacktor, 2002). These neurologic disorders are(More)