Paul G O'Keefe

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The parasitic dinoflagellate Hematodinium sp. causes a condition known as bitter crab disease (BCD) in snow crabs Chionoecetes opilio and Tanner crabs C. bairdi. As the name of the condition implies, crabs infected with BCD are unmarketable due to their bitter flavor. We surveyed the distribution of BCD in 3 regions within the snow crab fishery of(More)
Bitter crab disease (BCD) is caused by Hematodinium sp., an endoparasitic dinoflagellate. It lives within the hemocoeloms of snow crabs Chionoecetes opilio and Tanner crabs C. bairdi, making them unmarketable due to their bitter flavor. Two recent outbreaks of BCD have occurred in Conception Bay, Newfoundland, one from 1999 to 2000 and another from 2003 to(More)
Since the introduction of highly active antiretroviral therapy there has been an improvement in the quality of life for people with HIV infection. Despite the progress made, about 70% of HIV patients develop neurologic complications. These originate either in the central or the peripheral nervous system (Sacktor, 2002). These neurologic disorders are(More)
Infections of the central nervous system (CNS) in individuals with human immunodeficiency virus (HIV) remain a substantial cause of morbidity and mortality despite the introduction of highly active antiretroviral therapy (HAART) especially in the resource-limited regions of the world. Diagnosis of these infections may be challenging because findings on(More)
Chemotherapy offers the potential for cure or substantial palliation of numerous malignancies. However, its effective use requires a carefully developed strategy to overcome the barriers presented by a variety of neoplasms. Curative treatment for those human malignancies that show sensitivity to the available drugs requires combinations of drugs in "dose(More)