Paul Flondor

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In the present paper we define the (pseudo) MV-algebras with n-ary operators, generalizing MV-modules and product MV-algebras. Our main results assert that there are bijective correspondences between the operators defined on a pseudo MV-algebra and the operators defined on the corresponding `-group. We also provide a categorical framework and we prove the(More)
In order to evaluate the degree of endotoxin tolerance, expressed by the reduced cytokine/releasing capacity of the whole blood, data from a group of patients with trauma, severe acute pancreatitis (SAP), and diffuse peritonitis were analyzed. In SAP endotoxin levels and the tumor necrosing factor (TNF)– releasing capacity of the whole blood under(More)
The goal of this paper is to explain: (1) the low-level TNF-alpha concentration in some septic patients and (2) the relevance of the in vivo and in vitro models of endotoxin tolerance for the clinical sepsis. We hypothesized that the low level of TNF-alpha concentration in septic patients can be understood, at least in part, by two particularities of these(More)
The response to endotoxin (LPS), and subsequent signal transduction lead to the production of cytokines such as tumor necrosis factor-α (TNF-α) by innate immune cells. Cells or organisms pretreated with endotoxin enter into a transient state of hyporesponsiveness, referred to as endotoxin tolerance (ET) which represents a particular case of negative(More)
In a recent paper the authors hypothesized that the so called fractal-like enzyme kinetics of intracellular reactions may explain the preconditioning effect in biology (Vasilescu C, Olteanu M, Flondor P, Revue Roumaine de Chimie. 2011; 56(7): 751-7). Inside cells the reaction kinetics is very well described by fractal-like kinetics. In the present work some(More)