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BACKGROUND Recent technological advances have made it possible to efficiently genotype large numbers of single nucleotide polymorphisms (SNPs) in livestock species, allowing the production of high-density linkage maps. Such maps can be used for quality control of other SNPs and for fine mapping of quantitative trait loci (QTL) via linkage disequilibrium(More)
It is increasingly common to combine Microarray and Quantitative Trait Loci data to aid the search for candidate genes responsible for phenotypic variation. Workflows provide a means of systematically processing these large datasets and also represent a framework for the re-use and the explicit declaration of experimental methods. In this article, we(More)
BACKGROUND To date, several genome-scale network reconstructions have been used to describe the metabolism of the yeast Saccharomyces cerevisiae, each differing in scope and content. The recent community-driven reconstruction, while rigorously evidenced and well annotated, under-represented metabolite transport, lipid metabolism and other pathways, and was(More)
The Taverna workflow tool suite (http://www.taverna.org.uk) is designed to combine distributed Web Services and/or local tools into complex analysis pipelines. These pipelines can be executed on local desktop machines or through larger infrastructure (such as supercomputers, Grids or cloud environments), using the Taverna Server. In bioinformatics, Taverna(More)
SUMMARY By making scientific content more reusable, and providing a social infrastructure which facilitates sharing, the human aspects of the scholarly knowledge cycle may be accelerated and thereby reduce " time-to-discovery ". We introduce the notion of the Research Object – the work objects that are built, transformed and published in the course of(More)
SUMMARY Automation in science is increasingly marked by the use of workflow technology. The sharing of workflows through repositories supports the verifiability, reproducibility and extensibility of computational experiments. However, the subsequent discovery of workflows remains a challenge, both from a sociological and technological viewpoint. Based on a(More)
—The myExperiment social website for sharing scientific workflows, designed according to Web 2.0 principles, has grown to be the largest public repository of its kind. It is distinctive for its focus on sharing methods, its researcher-centric design and its facility to aggregate content into sharable 'research objects'. This evolution of myExperiment has(More)
  • Charles R. Beck, Bruce C. McKenzie, Ahmed B. Hashim, Rebecca C. Harris, Arina Zanuzdana, Gabriel Agboado +38 others
  • 2011
BACKGROUND Immunocompromised patients are vulnerable to severe or complicated influenza infection. Vaccination is widely recommended for this group. This systematic review and meta-analysis assesses influenza vaccination for immunocompromised patients in terms of preventing influenza-like illness and laboratory confirmed influenza, serological response and(More)
It is increasingly common to combine genome-wide expression data with quantitative trait mapping data to aid in the search for sequence polymorphisms responsible for phenotypic variation. By joining these complex but different data types at the level of the biological pathway, we can take advantage of existing biological knowledge to systematically identify(More)
There are several co-related activities in the database area and computer architecture that make the discussion of database machines and their implications on DBMS standards timely and meaningful. First, in the database area there is a drive toward more powerful database management systems which support high-level data models and languages. The motive for(More)