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Alzheimer's disease (AD) is characterized by the presence of extracellular deposits referred to beta-amyloid (Abeta) complexes or senile plaques. Abeta peptide is firstly produced as monomers, readily aggregating to form multimeric complexes, of which the smallest aggregates are known to be the most neurotoxic. In AD patients, abundant reactive microglia(More)
Neuroinflammation is the local reaction of the brain to infection, trauma, toxic molecules or protein aggregates. The brain resident macrophages, microglia, are able to trigger an appropriate response involving secretion of cytokines and chemokines, resulting in the activation of astrocytes and recruitment of peripheral immune cells. IL-1β plays an(More)
PURPOSE Platelet-derived growth factor (PDGF), a major mitogen and chemoattractant, is a dimeric molecule of disulfide-bonded A and/or B polypeptide chains (PDGF-AA/AB/BB). Two PDGF receptors (PDGFR) exist, alpha and beta, which dimerize after ligand exposure. The alpha-receptor binds both A- and B-chains, whereas the beta-receptor preferentially binds the(More)
Parkinson's disease (PD) is histologically described by the deposition of α-synuclein, whose accumulation in Lewy bodies causes dopaminergic neuronal death. Although most of PD cases are sporadic, point mutations of the gene encoding the α-synuclein protein cause inherited forms of PD. There are currently six known point mutations that result in familial(More)
w ED1 + lmacmphages, monocytes and dendritic cellsl and ED2+ cells ImacrophaQoa ordvl agpear to have a role in comeal rejection followinp pen&ti~ kerato&~~ in the rat. In the fdlowinp presentation the distribution of ED1 and ED2 wsitive cdls in normal weal tissues of Lewis rats, the influence of comeal transpiantation and the efIeci of Cwlnspuin A lCsAl(More)
Purpose: The authors report the results of more lhan 150 cases of long term culture for comeal storage at 31 'C. hWmds : An enucleation procedure is done before comeoscleral removal in the labixatory.under laminar flow hood.The media used are INOSOL and EXOSOL from OPSIA Endothelium evaluation is performed under microscope. Resuls : 25% of the wmeas are(More)
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