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Analogues of androsta-1,4-diene-3,17-dione (3a) in which the D ring is modified were prepared and tested as suicide inactivators and competitive inhibitors of human placental aromatase. As long as… (More)
The oxidation of ent-kaur-16-en-19-ol (2) by a microsomal enzyme preparation from M. macrocarpus seeds proceeds with sterospecific loss of the C-19 hydrogen atom in (2) which appears at higher field… (More)
(17R,S)-17-Hydroxy-14,15-secoandrost-4-en-15-yn-3-one has been shown previously to be a mechanism-based inactivator of rat liver 3 alpha-hydroxysteroid dehydrogenase. This manuscript describes the… (More)
Much in Frankenstein suggests that the novel and classical psychoanalysis are meant for each other. The creation becomes a significant act, at once paradigmatic and intensely human, when viewed as ...
braced by the "moving waters" of natural process. That watery embrace, Keats knows, is the prelude to a wintry shroud, and so he must pray for a steadfast commitment to a process that is at once… (More)