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RATIONALE Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) offer a powerful in vitro tool to investigate disease mechanisms and to perform patient-specific drug screening. To date, electrophysiological analysis of iPSC-CMs has been limited to single-cell recordings or low-resolution microelectrode array mapping of small cardiomyocyte(More)
Electroanatomic mapping the interrelation of intracardiac electrical activation with anatomic locations has become an important tool for clinical assessment of complex arrhythmias. Optical mapping of cardiac electrophysiology combines high spatiotemporal resolution of anatomy and physiological function with fast and simultaneous data acquisition. If applied(More)
We report the demonstration of a technique using resonant degenerate four-wave mixing to produce high-resolution, background-free images of atomic distributions in flames. Comparison with laser-induced-fluorescence methods and applications of the method to species of interest in combustion are briefly discussed.
Whole-heart multi-parametric optical mapping has provided valuable insight into the interplay of electrophysiological parameters, and this technology will continue to thrive as dyes are improved and technical solutions for imaging become simpler and cheaper. Here, we show the advantage of using improved 2nd-generation voltage dyes, provide a simple solution(More)
1 Introduction Coherent optical techniques contrast with those based on incoherent processes such as laser induced fluorescence or spontaneous Raman scattering by emitting a signal in a laser-like beam of radiation. For combustion diagnostics this presents obvious advantages for efficient collection of the signal and discrimination against background noise(More)
We report accurate and precise single-shot measurements of temperature and pressure using laser induced thermal grating spectroscopy (LITGS). The use of a flashlamp-pumped dye laser (FLPDL) as a probe for the induced gratings is described and a fast method of data analysis using Fourier methods is reported. Thermal gratings were induced by 8 ns pump pulses(More)