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Journals and Conferences
RATIONALE Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) offer a powerful in vitro tool to investigate disease mechanisms and to perform patient-specific drug screening. To date, electrophysiological analysis of iPSC-CMs has been limited to single-cell recordings or low-resolution microelectrode array mapping of small cardiomyocyte… (More)
The use of a novel modeless laser as the broadband source in multiplex CARS thermometry, by reducing the laser noise on the CARS spectra, is shown to give a precision of approximately 1 % in single-shot temperature measurements in nitrogen at 1200 K.
Electroanatomic mapping the interrelation of intracardiac electrical activation with anatomic locations has become an important tool for clinical assessment of complex arrhythmias. Optical mapping of cardiac electrophysiology combines high spatiotemporal resolution of anatomy and physiological function with fast and simultaneous data acquisition. If applied… (More)
We report the demonstration of a technique using resonant degenerate four-wave mixing to produce high-resolution, background-free images of atomic distributions in flames. Comparison with laser-induced-fluorescence methods and applications of the method to species of interest in combustion are briefly discussed.
Phase conjugate images are produced by resonant degenerate four-wave mixing from rotationally excited OH molecules in a premixed, laminar methane/air flame. By comparing signal intensities in the images produced using transitions from different rotational levels, the temperature map of a planar section of the flame is derived.
Whole-heart multi-parametric optical mapping has provided valuable insight into the interplay of electrophysiological parameters, and this technology will continue to thrive as dyes are improved and technical solutions for imaging become simpler and cheaper. Here, we show the advantage of using improved 2nd-generation voltage dyes, provide a simple solution… (More)
1 Introduction Coherent optical techniques contrast with those based on incoherent processes such as laser induced fluorescence or spontaneous Raman scattering by emitting a signal in a laser-like beam of radiation. For combustion diagnostics this presents obvious advantages for efficient collection of the signal and discrimination against background noise… (More)
Multi-mode absorption spectroscopy, MUMAS, in the near-infra-red is reported for the first time. A diode laser pumped Er/Yb:glass micro-cavity laser emitting multiple longitudinal modes at 1.53 microm was used to detect several transitions in the nu(1)+nu(3) overtone band of C2H2.
We report accurate and precise single-shot measurements of temperature and pressure using laser induced thermal grating spectroscopy (LITGS). The use of a flashlamp-pumped dye laser (FLPDL) as a probe for the induced gratings is described and a fast method of data analysis using Fourier methods is reported. Thermal gratings were induced by 8 ns pump pulses… (More)