Paul E Tomlins

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In biomedicine, titanium materials with specific surface textures (for example, those produced using consecutive polishing, sandblasting and acid etching) are widely used to facilitate osseointegration of human/animal tissue with implant surface structures. The surface texture has a critical role on the material‟s functionality in terms of cellular adhesion(More)
Multiwalled carbon nanotubes (MWCNTs) possess unique properties rendering them a potentially useful biomaterial for neurobiological applications such as providing nanoscale contact-guidance cues for directing axon growth within peripheral nerve repair scaffolds. The in vitro biocompatibility of MWCNTs with postnatal mouse spinal sensory neurons was assessed(More)
Quasi-elastic light scattering (QELS) and quartz crystal microbalance (QCM) non-equilibrium and equilibrium studies of competitive interactions of pairs of polymers and proteins with fumed silica and ceramic coatings deposited on QCM crystals show complex interfacial behaviour. The effects observed depend on the adsorption sequence of co-adsorbates, their(More)
Orthopaedic implants are designed to promote biocompatibility and hence their integration with surrounding tissue. This involves influencing cell-implant interactions through changes in both surface topography and surface roughness. However, the large range of machining techniques used in implant manufacture and inconsistencies in the measurement techniques(More)
There has been an immense amount of research activity in the emerging fi eld of regenerative medicine which dates back to the early 1980s and beyond, with many examples of products that have made the diffi cult transition from the laboratory to commercially available goods. This process, like many product developments, is fraught with issues that range from(More)
The initial attachment of cells to biomaterials is an important indicator of longer term cell-substrate biocompatibility. To study and quantify this interaction, we have developed a protocol for measuring temporal changes in the three-dimensional (3D) morphology of mammalian cells seeded onto different substrates using fluorescence confocal laser scanning(More)
Introduction: This study examined the use of military mobile hospitals for the provision of primary care in rural areas during four years. The Military Medical Service Department was ordered to send mobile hospitals to many different rural areas to: (1) provide primary care and treat patients; (2) refer cases to a larger hospital if necessary, using air(More)
Biocompatibility is key to the performance of any material in a biological environment. This review outlines current opinion on the factors that lead to biocompatibility and focuses on the interactions that occur at the interface between material and environment. The sequence of events, from protein adsorption, cell attachment and behavior, to(More)
We have investigated a potential test method to monitor changes through possible degradation of a collagen/glycosaminoglycan tissue engineering scaffold in vitro. The method used cyclic voltammetry where the degradation process was measured by determining changes in the apparent diffusion coefficients of thermodynamically reversible couples, ferrocyanide(More)
Hydrogels are playing an increasing role in regenerative medicine owing to their growing functional sophistication. This is being underpinned by advances in hydrogel synthesis, particularly through molecular and genetic engineering, which provide greater control of hydrogel structure and hence the emergence of hydrogels with new functionalities. In order to(More)