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CONTEXT In Israel, the mean annual incidence of hepatitis A disease was 50.4 per 100 000 during 1993-1998. A 2-dose universal hepatitis A immunization program aimed at children aged 18 and 24 months (without a catch-up campaign) was started in 1999. OBJECTIVE To observe the impact of toddlers-only universal vaccination on hepatitis A virus disease in(More)
High incidence of hereditary complement (C) deficiencies was found among 101 patients who had a meningococcal disease. This study revealed 11 non-related patients with complete C deficiency: five deficient in C7, three in C8, two in properdin and one in C2. Additional C-deficient individuals, most of them with no history of severe bacterial infections, were(More)
In 932 adult males and 531 adult females, we found large independent correlations of serum uric acid (SUA) with body mass and serum creatinine. In males, but not in females, SUA was lower in smokers than in non-smokers and in men who reported themselves to be physically active, compared to non-active men. After controlling for confounding variables by(More)
Despite the improved standard of living in Israel, shigellosis remains a common disease. Examination of trends in the incidence of shigellosis in Israel between 1951 and 1987 showed a period of declining rates followed by an increase in the reported incidence beginning around 1969. This increase was mainly due to Shigella sonnei; rates of infection with(More)
STUDY OBJECTIVES The incidence and prevalence of pertussis in adults have increased in recent years. It has been shown that previously immunized adults and adolescents are the main sources of transmission of Bordetella pertussis. The aim of this study was to describe the clinical presentation and the clinical course of pertussis in children and young adults(More)
An outbreak of 15 cases of paralytic poliomyelitis caused by type 1 poliovirus between July and October, 1988, prompted mass vaccination of the whole Israeli population under the age of 40 years. The focus of the outbreak (12 cases) was the Hadera subdistrict, one of two subdistricts where enhanced inactivated poliovaccine (eIPV) had been the only(More)
The introduction of live attenuated measles vaccine in Israel during 1967 dramatically decreased the incidence of measles. However, cases still occur in periodic outbreaks and epidemics, with an increasing proportion of infants and children younger than 2 years of age. We examined the decay of maternally derived measles antibody during the first year of(More)
Meningococcal disease accounts for approximately 20% of cases of bacterial meningitis in Israel. During the period 1951-1990, the annual incidence of meningococcal disease rarely exceeded two cases per 100,000 persons and was generally higher among non-Jews (largely the Arab population) than among Jews; there were some notable peaks of disease activity(More)
BACKGROUND Influenza is an annual winter disease which causes considerable morbidity in the general population and may be lethal in defined high-risk groups. A killed vaccine, recommended for the high-risk groups as well as for several occupational categories, is moderately protective against the disease, but vaccine sales suggest that use is low. METHODS(More)
Cutaneous leishmaniasis has long been endemic in Israel. After a 15-year period of moderate illness rates, reported incidence increased from 0.4 cases per 100,000 population in 2001 to 4.4 cases per 100,000 population in 2012, and the disease emerged in areas where its presence had previously been minimal. We analyzed all cases reported to the national(More)