Paul E. Belcher

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We invite biochemists, microbiologists and others who may be working with potential "target" proteins to learn more about the concepts of Fragment-based Drug Design, and to explore the potential of collaborating with our COBRE core research laboratories to apply this method to their proteins and the biological systems in which they function. At this time we(More)
BACKGROUND There is a pressing need for high-affinity protein binding ligands for all proteins in the human and other proteomes. Numerous groups are working to develop protein binding ligands but most approaches develop ligands using the same strategy in which a large library of structured ligands is screened against a protein target to identify a(More)
BACKGROUND There is a significant need for affinity reagents with high target affinity/specificity that can be developed rapidly and inexpensively. Existing affinity reagent development approaches, including protein mutagenesis, directed evolution, and fragment-based design utilize large libraries and/or require structural information thereby adding time(More)
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