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This report identifies the large-scale fabric configuration requirements of the emerging Grid world. We present a number of real-world case studies to illustrate how several different organizations currently manage large-scale system fabrics. We then examine some projected use cases that aim to predict the way in which large-scale system configuration will(More)
Molecular studies of bacterial virulence are enhanced by expression of recombinant DNA during infection to allow complementation of mutants and expression of reporter proteins in vivo. For highly pathogenic bacteria, such as Yersinia pestis, these studies are currently limited because deliberate introduction of antibiotic resistance is restricted to those(More)
We study the evolution of the network properties of a populated network embedded in a genotype space characterized by either a low or a high number of potential links, with particular emphasis on the connectivity and clustering. Evolution produces two distinct types of network. When a specific genotype is only able to influence a few other genotypes, the(More)
What features characterize complex system dynamics? Power laws and scale invariance of fluctuations are often taken as the hallmarks of complexity, drawing on analogies with equilibrium critical phenomena. Here we argue that slow, directed dynamics, during which the system's properties change significantly, is fundamental. The underlying dynamics is related(More)
In many metabolomics studies, NMR spectra are divided into bins of fixed width. This spectral quanti-fication technique, known as uniform binning, is used to reduce the number of variables for pattern recognition techniques and to mitigate effects from variations in peak positions; however, shifts in peaks near the boundaries can cause dramatic quantitative(More)
Organophosphates are a group of pesticides and chemical warfare nerve agents that inhibit acetylcholinesterase, the enzyme responsible for hydrolysis of the excitatory neurotransmitter acetylcholine. Numerous structural variants exist for this chemical class, and data regarding their toxicity can be difficult to obtain in a timely fashion. At the same time,(More)
We describe Data Science, a four-year undergraduate program in predictive analytics, machine learning, and data mining implemented at the College of Charleston, Charleston, South Carolina, USA. We present a ten-year status report detailing the program's origins, successes, and challenges. Our experience demonstrates that education and training for big data(More)