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BACKGROUND Patients with brain tumors who are treated with radiation frequently have growth hormone deficiency, but other neuroendocrine abnormalities are presumed to be uncommon. METHODS We studied endocrine function in 32 patients (age, 6 to 65 years) 2 to 13 years after they had received cranial radiotherapy for brain tumors. The doses of radiation to(More)
OBJECTIVE To study the changes in neuroautonomic regulation of heart rate and the effects of N(G)-nitro-L-arginine methyl ester (L-NAME), a competitive inhibitor of nitric oxide synthase, on efferent sympathetic cardiac activity and blood pressure during hypovolemic shock. Hypotension during hypovolemic shock may be attributable, in part, to the failure of(More)
The incidence and pattern of changes in thyroid function tests were studied in acutely hospitalized psychiatric patients and the cost effectiveness of a systematic screening program for thyroid dysfunction was estimated. Thyroid testing was performed on 1275 of 1424 (90%) admissions to the psychiatric wing of Strong Memorial Hospital between April 1, 1993(More)
The effects of acute severe illness on pituitary-gonadal function were determined in 35 men and 19 women, including 12 who were postmenopausal. Seventeen men and 5 women had traumatic brain injury which resulted in coma. Twelve postmenopausal and 2 premenopausal women had intracranial vascular accidents. Eleven men had myocardial infarctions, while 7 men(More)
Activation of the sympathetic nervous system attends traumatic brain injury, but the association of the severity of neurological impairment and recovery with the extent of sympathetic nervous system stimulation is poorly defined. In this study, plasma norepinephrine (NE), epinephrine (E), and dopamine (DA) levels were measured serially in 33 patients with(More)
OBJECTIVE To study and compare the autonomic cardiovascular state of children after severe brain injury and brain death. DESIGN Prospective clinical study. SETTING Pediatric ICU. PATIENTS Pediatric patients suffering severe brain injury caused by trauma, anoxia, or hemorrhage. INTERVENTION None. MEASUREMENTS AND MAIN RESULTS We analyzed(More)
During stress, low-frequency (0.01-0.15 Hz) heart rate power and plasma catecholamine levels increase in response to increased sympathetic efferent activity. To test the hypothesis that low-frequency heart rate power, a measure of sympathetic control of heart rate, directly correlates with plasma catecholamine concentrations during periods of increased(More)