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  • Anar Akhmedov, Scott Baldridge, R Inanç Baykur, Paul Kirk, B Doug Park
  • 2007
For each pair (e, σ) of integers satisfying 2e + 3σ ≥ 0, σ ≤ −2, and e + σ ≡ 0 (mod 4), with four exceptions, we construct a minimal, simply connected symplectic 4-manifold with Euler characteristic e and signature σ. We also produce simply connected, minimal sym-plectic 4-manifolds with signature zero (resp. signature −1) with Euler characteristic 4k(More)
MOTIVATION The growing field of systems biology has driven demand for flexible tools to model and simulate biological systems. Two established problems in the modeling of biological processes are model selection and the estimation of associated parameters. A number of statistical approaches, both frequentist and Bayesian, have been proposed to answer these(More)
BACKGROUND Post-genomic molecular biology has resulted in an explosion of data, providing measurements for large numbers of genes, proteins and metabolites. Time series experiments have become increasingly common, necessitating the development of novel analysis tools that capture the resulting data structure. Outlier measurements at one or more time points(More)
Chaos and oscillations continue to capture the interest of both the scientific and public domains. Yet despite the importance of these qualitative features, most attempts at constructing mathematical models of such phenomena have taken an indirect, quantitative approach, for example, by fitting models to a finite number of data points. Here we develop a(More)
BACKGROUND Human T lymphotropic virus Type 1 (HTLV-1) causes a chronic inflammatory disease of the central nervous system known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM) which resembles chronic spinal forms of multiple sclerosis (MS). The pathogenesis of HAM remains uncertain. To aid in the differential diagnosis of HAM and to(More)
The recruitment and migration of macrophages and neutrophils is an important process during the early stages of the innate immune system in response to acute injury. Transgenic pu.1:EGFP zebrafish permit the acquisition of leukocyte migration trajectories during inflammation. Currently, these high-quality live-imaging data are mainly analysed using general(More)
The pathogenesis of HAM remains uncertain: the disease is thought to be caused by the immune response to HTLV-1, possibly by bystander damage to neurons in the spinal cord. The strongest correlate of HAM in HTLV-1-infected individuals is the proviral load of HTLV-1, i.e. the percentage of peripheral blood mono-nuclear cells that carry the provirus. To aid(More)
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