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BACKGROUND AND OBJECTIVES Gastro-oesophageal reflux disease (GORD) is a common gastrointestinal disorder with a genetic component. Our aim was to identify genetic factors associated with GORD. PATIENTS AND METHODS Four separate patient cohorts were analysed using a step-wise approach. (1) Whole genome linkage analysis was performed in 36 families. (2)(More)
BACKGROUND Postnatal growth of the small intestine occurs by crypt hyperplasia and by the less recognised mechanism of crypt fission. How the small intestine grows is largely extrapolated from animals and is poorly described in humans. AIM To investigate crypt fission and crypt hyperplasia as mechanisms of intestinal growth in humans. PATIENTS AND(More)
BACKGROUND The mouse model using a human isolate of Helicobacter pylori is being widely accepted as an economical means of studying gastric infection. A noninvasive monitoring method would be useful for repeated testing to establish the time course of infection and the efficacy of treatments. In this study, we describe factors that affected interpretation(More)
OBJECTIVE To evaluate the validity of a parental questionnaire used to screen preschool children for persistent hearing impairment. METHODOLOGY Six-hundred and eighty-five children aged 4-5 years from a Metropolitan area of Adelaide, Australia, were enrolled. Each parent completed a questionnaire aimed at detecting parental concerns about hearing(More)
Background. There are no previous reports of tandem balloon dilatation in childhood achalasia. Objective. To report the treatment of four cases of paediatric achalasia using tandem balloon dilatation of the lower oesophageal sphincter. A review of the literature since 1986 was undertaken to compare outcomes of balloon dilatation and surgery. Materials and(More)
From those responding to a newspaper advertisement, 29 female subjects were placed in one of four treatment groups aimed at overcoming sexual unassertiveness. The four groups were: Social Skills Training (SST); Cognitive Restructuring (CR); a combined SST and CR group; and a nondirective placebo discussion group. All treatment groups received four two-hour(More)
Gastro-esophageal reflux disease (GERD) is partly caused by genetic factors. The underlying susceptibility genes are currently unknown, with the exception of COL3A1. We used three independent GERD patient cohorts to identify GERD susceptibility genes. Thirty-six families, demonstrating dominant transmission of GERD were subjected to whole genome(More)
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