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BACKGROUND A therapy that slows disease progression is the major unmet need in Parkinson's disease. METHODS In this double-blind trial, we examined the possibility that rasagiline has disease-modifying effects in Parkinson's disease. A total of 1176 subjects with untreated Parkinson's disease were randomly assigned to receive rasagiline (at a dose of(More)
Today's call center managers face multiple operational decision-making tasks. One of the most common is determining the weekly staffing levels to ensure customer satisfaction and meeting their needs while minimizing service costs. An initial step for producing the weekly schedule is forecasting the future system loads which involves predicting both arrival(More)
By investigating a Markov chain whose limiting distribution corresponds to that of the Dirichlet process we are able directly to ascertain conditions for the existence of linear functionals of that process. Together with earlier analyses we are able to characterize those functionals which are a.s. finite in terms of the parameter measure of the process. We(More)
For autoregressivetime series with positive innovationswhich either have heavy right or left tails, linear programming parameter estimates of the autoregressive coeecients have good rates of convergence. However, the asymptotic distribution of the estimators depends heavily on the distribution of the process and thus cannot be used for inference. A(More)
To investigate in real time if and how natural gravity affects rates of swim-up and swim-down of human spermatozoa, samples of motile or immobilized spermatozoa in a sealed mini-chamber were placed vertically on a 90 degrees tilted microscope. The mode of their sedimentation, as well as the difference in the rate of their swimming up and down, were observed(More)
A call center is a service operation that caters to customer needs via the telephone. Call centers typically consist of agents that serve customers, telephone lines, an Interactive Voice Response (IVR) unit, and a switch that routes calls to agents. In this paper we study a Markovian model for a call center with an IVR. We calculate operational performance(More)
OBJECTIVES We sought to assess the added diagnostic value of peripheral artery tonometric (PAT) measurements, based on finger pulsatile arterial volume changes, to standard 12-lead stress electrocardiography (ECG), for detecting exercise-induced myocardial ischemia, using single-photon emission computed tomography (SPECT) as the standard of comparison in a(More)
Monoamine oxidase A (MAOA) catalyses the oxidative deamination of biogenic amines including neurotransmitters, mainly norepinephrine and serotonin in the brain and peripheral tissues. A nonsense mutation in the gene was shown to be involved in a rare X-linked behavioural syndrome, which includes impaired impulse control, aggression and borderline mental(More)
To suggest a method for evaluating the accuracy of different kinds of sperm counting chambers by eliminating errors concerned with human skills or semen properties. In this method, various concentrations were prepared from stocks of commercially available latex beads (Accu-beads, Hamilton-Thorn Research, Beverly, MA). Samples from identical preparations(More)
Bacterial and viral infections are often clinically indistinguishable, leading to inappropriate patient management and antibiotic misuse. Bacterial-induced host proteins such as procalcitonin, C-reactive protein (CRP), and Interleukin-6, are routinely used to support diagnosis of infection. However, their performance is negatively affected by inter-patient(More)