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The hepatitis C virus (HCV) internal ribosome entry site (IRES) is recognized specifically by the small ribosomal subunit and eukaryotic initiation factor 3 (eIF3) before viral translation initiation. Using extensive mutagenesis and structure probing analysis, we show that the eIF3-binding domain of the HCV IRES contains an internal loop structure (loop(More)
Non destructive evaluation of metallic, spherical pressure vessels is crucial to the safety and operations of a plant due to the large volume of hazardous products stored at high pressures. Sizes of such spheres vary and diameters may range from 10 to 25 meters, even more, while total length of welds can be hundreds of meters. Additionally, accessibility(More)
Poly(ADP-ribose)polymerase-1 (PARP-1) is a highly abundant chromatin-associated enzyme present in all higher eukaryotic cell nuclei, where it plays key roles in the maintenance of genomic integrity, chromatin remodeling and transcriptional control. It binds to DNA single- and double-strand breaks through an N-terminal region containing two zinc fingers, F1(More)
Landfills have the potential to mobilize arsenic via induction of reducing conditions in groundwater and subsequent desorption from or dissolution of arsenic-bearing iron phases. Laboratory incubation experiments were conducted with materials from a landfill where such processes are occurring. These experiments explored the potential for induced sulfate(More)
The Self as a Center of Narrative Gravity What is a self? I will try to answer this question by developing an analogy with something much simpler, something which is nowhere near as puzzling as a self, but has some properties in common with selves. What I have in mind is the center of gravity of an object. This is a well-behaved concept in Newtonian(More)
The continued high prevalence of oral contraceptive (OC) use by young women warrants the careful study of these agents. At present, it appears that the risk of benign breast disease is reduced by use of OCs. This effect seems to be greater for fibrocystic disease than for fibroadenoma. Available information suggests that, as yet, OC use has not had any(More)
A histologic study was conducted of sagittal sections of the genital tracts of 281 autopsied female stillborns and neonates. The prevalence of vaginal adenosis among 43 offspring exposed in utero to diethylstilbestrol (DES) was 70%, a frequency 18 times greater than the 4% prevalence among 159 unexposed offspring. The relationship of the prevalence of(More)
We introduce a simplified model for thin layer flows of granular materials with yield. The model is derived from a Drucker–Prager rheology, and describes the dynamics of the velocity profile and of the transition between static and flowing material. We compare the analytical solution in the inviscid case, and the numerical solution in the viscous case, to(More)