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The hepatitis C virus (HCV) internal ribosome entry site (IRES) is recognized specifically by the small ribosomal subunit and eukaryotic initiation factor 3 (eIF3) before viral translation initiation. Using extensive mutagenesis and structure probing analysis, we show that the eIF3-binding domain of the HCV IRES contains an internal loop structure (loop(More)
Non destructive evaluation of metallic, spherical pressure vessels is crucial to the safety and operations of a plant due to the large volume of hazardous products stored at high pressures. Sizes of such spheres vary and diameters may range from 10 to 25 meters, even more, while total length of welds can be hundreds of meters. Additionally, accessibility(More)
Poly(ADP-ribose)polymerase-1 (PARP-1) is a highly abundant chromatin-associated enzyme present in all higher eukaryotic cell nuclei, where it plays key roles in the maintenance of genomic integrity, chromatin remodeling and transcriptional control. It binds to DNA single- and double-strand breaks through an N-terminal region containing two zinc fingers, F1(More)
The Self as a Center of Narrative Gravity What is a self? I will try to answer this question by developing an analogy with something much simpler, something which is nowhere near as puzzling as a self, but has some properties in common with selves. What I have in mind is the center of gravity of an object. This is a well-behaved concept in Newtonian(More)
We introduce a simplified model for thin layer flows of granular materials with yield. The model is derived from a Drucker–Prager rheology, and describes the dynamics of the velocity profile and of the transition between static and flowing material. We compare the analytical solution in the inviscid case, and the numerical solution in the viscous case, to(More)
A new experiment, the forward directed quantitative gamma-HCCH-TOCSY for the measurement of the conformation of the five-membered ribosyl unit in RNA oligonucleotides, is presented. The experiment relies on quantification of cross peak intensities caused by evolution of CH, CH-dipole-dipole cross correlated relaxation in non-evolution periods and the(More)
This panel will present initial findings on the design, pilot implementation and research of TeamRoom, an innovative Louts Notes application. The application was designed initially to support temporary task teams and was extended to support ongoing , distributed and co-located work and management teams. TeamRoom represents early exploration into the(More)
The Environmental Monitoring and Assessment Program (EMAP) is an interagency effort coordinated by the U.S. Environmental Protection Agency and designed to collect information to assess the condition of the nation's ecological resources. The Information Management System for EMAP was developed to capture, preserve, and provide to users data and information(More)
  • Paul Cole
  • 2014
Unlike the position in the United States following the recent Supreme Court decision in Myriad, in the European Union naturally occurring genetic sequences, whether of human or other origin, remain patent-eligible. Here the basis for such eligibility in legislation and in case law is explained. The utility of a sequence must be disclosed as a condition of(More)