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Recent clinical successes with antibodies have reinvigorated interest in the identification and validation of new antigens for antibody therapy, including cell surface proteins for targeting in oncology, the focus of this review. Target identification commonly involves the search for differences between tumor and non-tumor cell lines and/or tissue at the(More)
In New Zealand and Australia, the BRACElet project has been investigating students' acquisition of programming skills in introductory programming courses. The project has explored students' skills in basic syntax, tracing code, understanding code, and writing code, seeking to establish the relationships between these skills. This ITiCSE working group report(More)
We describe an experience using online multimedia instruction and just-in-time teaching in an introductory programming course. Survey data has shown that students are strongly in favour of the approach. A series of screencasts was developed to replace the traditional lecture component of the course. Students were asked to review a small number of(More)
Phage display is a simple yet powerful technology that is used to rapidly characterize protein-protein interactions from amongst billions of candidates. This widely practiced technique is used to map antibody epitopes, create vaccines and to engineer peptides, antibodies and other proteins as both diagnostic tools and as human therapeutics. We overview the(More)
This paper outlines ProSynth, an approach to speech synthesis which takes a rich linguistic structure as central to the generation of natural-sounding speech. We start from the assumption that the acoustic richness of the speech signal reflects linguistic structural richness and underlies the percept of naturalness. Naturalness achieved by paying attention(More)
The current conduction pathways resulting from monopolar stimulation of the cochlear implant were studied by developing a human electroanatomical total head reconstruction (namely, HEATHER). HEATHER was created from serially sectioned images of the female Visible Human Project dataset to encompass a total of 12 different tissues, and included computer-aided(More)
Numerical studies indicate that the FitzHugh–Nagumo system exhibits stable traveling pulses with os-cillatory tails. In this paper, the existence of such pulses is proved analytically in the singular perturbation limit near parameter values where the FitzHugh–Nagumo system exhibits folds. In addition, the stability of these pulses is investigated(More)
Tumours of the vulva and vagina are rare and there are relatively few studies of circulating markers in these conditions. The urinary measurement of the core fragment of the beta-subunit of hCG has been proposed as a useful tumour marker in non-trophoblastic gynaecological malignancies. This study describe the measurement of urinary beta-core in 50 patients(More)
GOAL To validate a new electroanatomical model of the implanted guinea pig cochlea against independently obtained in vivo voltage tomography data, and evaluate the validity of exist-ing modeling assumptions on current paths and neural excitation. METHODS An in silico model was generated from sTSLIM images and analyzed in COMSOL Multiphysics. Tissue(More)