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The current conduction pathways resulting from monopolar stimulation of the cochlear implant were studied by developing a human electroanatomical total head reconstruction (namely, HEATHER). HEATHER was created from serially sectioned images of the female Visible Human Project dataset to encompass a total of 12 different tissues, and included computer-aided(More)
We describe an experience using online multimedia instruction and just-in-time teaching in an introductory programming course. Survey data has shown that students are strongly in favour of the approach. A series of screencasts was developed to replace the traditional lecture component of the course. Students were asked to review a small number of(More)
This paper describes an experiment with online instruction and active learning in an introductory computing course for engineering students. A series of online screencasts was developed to replace the traditional component of lectures for a one week period in the middle of the course. Students were asked to review the screencasts before coming to class and(More)
We have examined the plasticity of the antigen-combining site of a high-affinity antibody. In phage-displayed Fab libraries, selected CDR positions and one FR position of the humanized anti-Her2 antibody hu4D5 were substituted with all 20 amino acids. Antigen-binding selections were used to enrich for high-affinity variants, and a large number of sequences(More)
It is known that the inclusion of blood vessels in finite element (FE) models can influence the current conduction results. However, there have been no studies exploring the impact of blood vessel conductivity on human head models for cochlear implant (CI) stimulation. The three-dimensional (3D) FE model presented in this paper aims to provide understanding(More)
Electrostatic forces arising from charge accumulation on drug and excipient powders cause agglomeration and adhesion of particles to solid surfaces and problems during the manufacture and use of many pharmaceutical dosage forms, including dry powder inhalers (DPIs). The ability of materials to dissipate the acquired charge is therefore important and the aim(More)
Electrostatic charge accumulation on drug and excipient powders arising from interparticulate collisions or contacts between particles and other solid surfaces often leads to agglomeration and adhesion problems during the manufacture and use of dry powder inhaler (DPI) formulations. The aim of this work was to investigate the role of triboelectrification in(More)
GOAL To validate a new electroanatomical model of the implanted guinea pig cochlea against independently obtained in vivo voltage tomography data, and evaluate the validity of exist-ing modeling assumptions on current paths and neural excitation. METHODS An in silico model was generated from sTSLIM images and analyzed in COMSOL Multiphysics. Tissue(More)
In New Zealand and Australia, the BRACElet project has been investigating students' acquisition of programming skills in introductory programming courses. The project has explored students' skills in basic syntax, tracing code, understanding code, and writing code, seeking to establish the relationships between these skills. This ITiCSE working group report(More)
Phage display is a simple yet powerful technology that is used to rapidly characterize protein-protein interactions from amongst billions of candidates. This widely practiced technique is used to map antibody epitopes, create vaccines and to engineer peptides, antibodies and other proteins as both diagnostic tools and as human therapeutics. We overview the(More)