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We have examined the plasticity of the antigen-combining site of a high-affinity antibody. In phage-displayed Fab libraries, selected CDR positions and one FR position of the humanized anti-Her2 antibody hu4D5 were substituted with all 20 amino acids. Antigen-binding selections were used to enrich for high-affinity variants, and a large number of sequences(More)
Electrostatic charge accumulation on drug and excipient powders arising from interparticulate collisions or contacts between particles and other solid surfaces often leads to agglomeration and adhesion problems during the manufacture and use of dry powder inhaler (DPI) formulations. The aim of this work was to investigate the role of triboelectrification in(More)
Electrostatic forces arising from charge accumulation on drug and excipient powders cause agglomeration and adhesion of particles to solid surfaces and problems during the manufacture and use of many pharmaceutical dosage forms, including dry powder inhalers (DPIs). The ability of materials to dissipate the acquired charge is therefore important and the aim(More)
In New Zealand and Australia, the BRACElet project has been investigating students' acquisition of programming skills in introductory programming courses. The project has explored students' skills in basic syntax, tracing code, understanding code, and writing code, seeking to establish the relationships between these skills. This ITiCSE working group report(More)
We describe an experience using online multimedia instruction and just-in-time teaching in an introductory programming course. Survey data has shown that students are strongly in favour of the approach. A series of screencasts was developed to replace the traditional lecture component of the course. Students were asked to review a small number of(More)
This paper describes an experiment with online instruction and active learning in an introductory computing course for engineering students. A series of online screencasts was developed to replace the traditional component of lectures for a one week period in the middle of the course. Students were asked to review the screencasts before coming to class and(More)
The current conduction pathways resulting from monopolar stimulation of the cochlear implant were studied by developing a human electroanatomical total head reconstruction (namely, HEATHER). HEATHER was created from serially sectioned images of the female Visible Human Project dataset to encompass a total of 12 different tissues, and included computer-aided(More)
This paper presents results of a phonetic analysis of instances of lexical self-repair drawn from a corpus of spontaneous Dutch speech. The analysis addresses questions concerning the phonetic details of prosodic marking in self-repair and its conditioning factors. In particular, it examines the relevance of semantic, temporal and frequency-related factors(More)
This paper reports on a study of the temporal characteristics of phonological error repair in spontaneous Dutch speech, with a focus on how the articulation rate of the correct target word production — the repair — compares to that of the preceding erroneous target word attempt — the reparandum. The study is motivated by two findings from recent independent(More)
Cochlear implants have been one of most successful electronic devices implanted to human bodies to convert mechanical signals to electronic signals to stimulate auditory nerves to react. The current flow in the region of the cochlear is the key to determine the performance of Cochlear implants. One of the efforts could be made to reduce current leakage into(More)