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  • Bernard Fermini, Jules C. Hancox, +19 authors Jamie I. Vandenberg
  • Medicine, Biology
  • Journal of biomolecular screening
  • 2016 (First Publication: 1 January 2016)
  • For the past decade, cardiac safety screening to evaluate the propensity of drugs to produce QT interval prolongation and Torsades de Pointes (TdP) arrhythmia has been conducted according to ICH S7BContinue Reading
  • Paul Michael Scola, Li-qiang Sun, +47 authors Fiona McPhee
  • Biology, Medicine
  • Journal of medicinal chemistry
  • 2014 (First Publication: 13 March 2014)
  • The discovery of asunaprevir (BMS-650032, 24) is described. This tripeptidic acylsulfonamide inhibitor of the NS3/4A enzyme is currently in phase III clinical trials for the treatment of hepatitis CContinue Reading
  • Daniel C. Millard, Qianyu Dang, +17 authors Gary A. Gintant
  • Biology, Medicine
  • Toxicological sciences : an official journal of…
  • 2018 (First Publication: 1 August 2018)
  • Recent in vitro cardiac safety studies demonstrate the ability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to detect electrophysiologic effects of drugs. However,Continue Reading
  • Paul Michael Scola, Alan X. Wang, +46 authors Fiona McPhee
  • Medicine, Chemistry
  • Journal of medicinal chemistry
  • 2014 (First Publication: 13 March 2014)
  • The discovery of BMS-605339 (35), a tripeptidic inhibitor of the NS3/4A enzyme, is described. This compound incorporates a cyclopropylacylsulfonamide moiety that was designed to improve the potencyContinue Reading
  • Yoon Tag Jeon, Wu Yang, +30 authors Patrick Lam
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2014 (First Publication: 1 March 2014)
  • Spiropiperidine indoline-substituted diaryl ureas had been identified as antagonists of the P2Y1 receptor. Enhancements in potency were realized through the introduction of a 7-hydroxyl substitutionContinue Reading
  • Amanda Benjamin, David J. Gallacher, +8 authors Jean-Pierre Valentin
  • Medicine
  • Journal of pharmacological and toxicological…
  • 2015 (First Publication: 1 September 2015)
  • INTRODUCTION With the recent development of more sensitive biomarkers to assess kidney injury preclinically, a survey was designed i) to investigate what strategies are used to investigate renalContinue Reading