Superconducting and structural properties of strontium-substituted YBa2Cu4O8
- P. Karen, A. Kjekshus, S. Christensen
Attempted functionalisation of a mononuclear barium complex of a 24-membered bibracchial tetraimine Schiff-base macrocycle derived from tris(2-aminoethyl)amine using salicylaldehyde
- N. A. Bailey, C. Barbarín, Philip B. Leeson
Functionalisation of a mononuclear barium Complex of a 24-membered bibracchial tetraimine Schiff-base Macrocycle (L1) derived from the barium-templated cyclocondensation of 2,6-diacetylpyridine and…
Fundamental Study on Mechanisms of Thermal Decomposition and Oxidation of Aluminum Hydride
- Muye Feng, Heping Li, Q. Mao, K. Luo, Paul C. Hellier
- 13 September 2019
Journal of Physical Chemistry C
Aluminum hydride (AlH3) has great potential for a variety of propulsion and energy-storage applications. In this study, the ReaxFF reactive force field molecular dynamics simulation is employed to ...
Second-Generation Process Research Towards Eletriptan: A Fischer Indole Approach
- Christopher P. Ashcroft, Paul C. Hellier, A. Pettman, S. Watkinson
- 21 January 2011
The development of a second-generation process for the synthesis of eletriptan via a Fischer indole cyclisation is described. The finalised process offers several potential advantages over the…
Rapid Generation and Safe Use of Carbenes Enabled by a Novel Flow Protocol with In-line IR spectroscopy.
- Simon T. R. Müller, Aurélien Murat, Delphine Maillos, P. Lesimple, Paul C. Hellier, T. Wirth
- 4 May 2015
A powerful new continuous process for the formation and use of donor/acceptor-substituted carbenes is described. The safety profile of diazo group transfer on methyl phenylacetate was determined…
Toward a Large-Scale Approach to Milnacipran Analogues Using Diazo Compounds in Flow Chemistry
- Simon T. R. Müller, Aurélien Murat, Paul C. Hellier, T. Wirth
- 19 February 2016
Different separation techniques in flow are compared with regard to their ability to produce pure and dry diazo reagents and yield a scalable process to a key intermediate in the syntheses of milnacipran and its possible substituted analogues.
Ethyl Lithiodiazoacetate: Extremely Unstable Intermediate Handled Efficiently in Flow.
- Simon T. R. Müller, Tobias Hokamp, Svenja Ehrmann, Paul C. Hellier, T. Wirth
- 16 August 2016
A continuous flow protocol is reported that overcomes the problems associated with the instantaneous decomposition of ethyl lithiodiazoacetate and provides direct access to tertiary diazoalcohols in good yields.
Synthesis and Application of Macrocyclic and Macroacyclic Schiff Bases
- P. Guerriero, P. A. Vigato, D. E. Fenton, Paul C. Hellier
- 23 February 1993
Synthesis of fluorinated catharanthine analogues and investigation of their biomimetic coupling with vindoline.
- E. Giovanelli, Lionel Moisan, E. Doris
- 14 August 2013
Organic and biomolecular chemistry
The biomimetic coupling of the fluorinated catharanthine derivatives with vindoline led to unexpected alkaloid structures, the formation of which was rationalized.
On the elucidation of the mechanism of Vinca alkaloid fluorination in superacidic medium.
- E. Giovanelli, S. Leroux, E. Doris
- 6 July 2011
Detailed investigations on one of the key steps of the superacidic fluorination of Vinca alkaloids that is the origin of C20' activation are reported, and isotopic labeling experiments unambiguously revealed the involvement of a 1,2-hydride shift mechanism.