Paul C. Driscoll

Learn More
Multidomain proteins incorporating interaction domains are central to regulation of cellular processes. The elucidation of structural organization and mechanistic insights into many of these proteins, however, remain challenging due to their inherent flexibility. Here, we describe the organization and function of four interaction domains in PLCγ1 using a(More)
HLA B8-restricted cytotoxic T lymphocytes (CTL) specific for influenza A virus were generated and shown to recognize the nucleoprotein (NP). The dominant epitope was mapped using recombinant vaccinia viruses that expressed fragments of the NP and then synthetic peptides based on the NP amino acid sequence. The peptide 380-393 was first identified and(More)
The nonstructural protein NS1 of influenza A/PR/8/34 virus has previously been reported to be recognized by murine Kk-restricted cytotoxic T lymphocytes (CTL), although the sequence of the epitope was not defined. A Kk-specific motif has previously been published and consists of a glutamic acid or (less frequently) an aspartic acid at position 2 and an(More)
Class I molecules of the major histocompatibility complex (MHC) bind peptides derived from cytoplasmic proteins. Comparison of over 100 such peptides reveals the importance of the carboxy-terminal residue in selective binding. Recent evidence implicates the proteases and transporters of the processing pathway in providing peptides with the correct residues(More)
  • 1