Paul Brancato

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Young male Holtzman rats were injected intravenously with 50 mg/kg of Streptozotocin, preceded and followed by a single intraperitoneal injection of 350 mg/kg of nicotinamide, according to the method of Rakieten et al. [16]. After 245 to 323 days, 27 pancreatic islet cell tumors measuring up to 0.6 cm were demonstrable in 20 of 41 rats so treated; they were(More)
Seventy-seven male, 12 to 16 week old CD-1 mice were injected subcutaneously with the M variant of the enoephalomyocarditis (EMC) virus. Thirteen saline-injected mice served as controls. The 45 surviving virus-injected mice were sacrificed at intervals ranging from 24 h to 15 days following injection. Blood glucose values were distinctly elevated during the(More)