Paul Berman

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We have engineered two Chinese hamster ovary cell lines secreting different recombinant glycoproteins to express high levels of human beta1,4-galactosyltransferase (GT, E.C. 2.4.1.38) and/or alpha2, 3-sialyltransferase (ST, E.C. 2.4.99.6). N-linked oligosaccharide structures synthesized by cells overexpressing the glycosyltransferases showed greater(More)
Four boys with facial-digital-genital or Aarskog syndrome were whort with triangular faces, characteristic deformities of the hands and feet, and anomalies of the external genitalia. The syndrome appears to be inherited in an X-chromosomes-limked recessive manner. Previous reports emphasized the presence of hypertelorism but careful measurements of the(More)
Urinary tract infections in the elderly are common, often asymptomatic and usually benign. We report three patients who presented with acute renal failure due to acute pyelonephritis in the absence of clinical findings of infection or urinary tract obstruction. Blood and urine cultures grew Escherichia coli in two of the patients and in two patients renal(More)
There is evidence that the initial interaction between HIV-1 and the host that is essential for infection is the specific binding of the viral envelope glycoprotein, gp120, to the CD4 molecule found on certain T cells and monocytes. Most individuals infected with HIV develop antibodies against the gp120 protein. Although in vitro treatment of CD4+ T cells(More)
L-Lactate, D-lactate, and lactate dehydrogenase (LDH) levels were measured in the resting gastric juice of 73 patients and mean levels were found to be significantly higher in patients with gastric carcinoma than in those with benign gastric ulcer or those with normal stomachs. Raised levels of gastric juice L-lactate (greater than 1.3 mmol/l), D-lactate(More)
The Cancer Genome Atlas (TCGA) project has analyzed mRNA expression, miRNA expression, promoter methylation, and DNA copy number in 489 high-grade serous ovarian adenocarcinomas (HGS-OvCa) and the DNA sequences of exons from coding genes in 316 of these tumors. These results show that HGS-OvCa is characterized by TP53 mutations in almost all tumors (96%);(More)
A 14-year-old boy was admitted with a five-day history of progressive weakness affecting all four limbs. Three weeks earlier he had developed a productive cough which had been successfully treated with talampicillin. He suffered from asthma and was receiving sodium cromoglycate. On examination there was widespread inspiratory wheeze and a flaccid(More)