Paul B. Kavanagh

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UNLABELLED We have developed a completely automatic algorithm to quantitatively measure left ventricular ejection fraction (LVEF) from gated 99mTc-sestamibi myocardial perfusion SPECT images. METHODS The algorithm operates in the three-dimensional space and uses gated short-axis image volumes. It segments the left ventricle (LV), estimates and displays(More)
BACKGROUND The incremental prognostic value of post-stress left ventricular ejection fraction (EF) and volume over perfusion has not been investigated. METHODS AND RESULTS We identified 1680 consecutive patients who underwent rest Tl-201/stress Tc-99m sestamibi gated single photon emission computed tomography (SPECT) and who were followed-up for 569+/-106(More)
OBJECTIVES This study sought to assess whether a transient ischemic dilation ratio, determined from automatically derived stress and rest left ventricular volumes during stress technetium-99m (Tc-99m) sestamibi/rest thallium-201 dual-isotope myocardial perfusion single-photon emission computed tomography (SPECT), is useful for the identification of patients(More)
UNLABELLED This study investigates the feasibility of routine clinical 201Tl gated perfusion SPECT (gated Tl), and compares quantitative left ventricular ejection fraction (LVEF) and visually-assessed regional wall motion and thickening to analogous values obtained from 99mTc-sestamibi gated perfusion SPECT (gated MIBI). METHODS We studied 121 patients(More)
UNLABELLED We have developed a new, completely automatic 3-dimensional software approach to quantitative perfusion SPECT. The main features of the software are myocardial sampling based on an ellipsoid model; use of the entire count profile between the endocardial and epicardial surfaces; independence of the algorithm from myocardial shape, size, and(More)
Cedars-Sinai's approach to the automation of gated perfusion single photon emission computed tomography (SPECT) imaging is based on the identification of key procedural steps (processing, quantitation, reporting), each of which is then implemented, in completely automated fashion, by use of mathematic algorithms and logical rules combined into expert(More)
  • Cigdem Akincioglu, Daniel S Berman, +6 authors Guido Germano
  • Journal of nuclear medicine : official…
  • 2005
UNLABELLED The purposes of this study were (a) to assess the feasibility of diastolic function (DFx) evaluation using standard 16-frame postexercise gated (99m)Tc-sestamibi myocardial perfusion SPECT (MPS), (b) to determine the relationship of the 2 common DFx parameters, peak filling rate (PFR) and time to peak filling (TTPF), to clinical and systolic(More)
UNLABELLED This study validates a new quantitative perfusion SPECT algorithm for the assessment of myocardial perfusion. The algorithm is not based on slices and provides fully 3-dimensional sampling and analysis independent of assumptions about the geometric shape of the left ventricle. METHODS Radiopharmaceutical- and sex-specific normal limits and(More)
UNLABELLED We developed a completely automatic technique to reorient transaxial images into short-axis (oblique) myocardial perfusion SPECT images. METHODS The algorithm starts by isolating (segmenting) the left ventricle (LV) myocardium using a combination of iterative clusterification and rule-based location/size/shape criteria. The three-dimensional,(More)
METHODS We have developed a protocol, termed "temporal image fractionation," in which static myocardial perfusion SPECT studies are acquired as three-interval dynamic studies (three temporal frames, each consisting of a full projection set), utilizing continuous alternating detector rotation and a multi-detector camera. The frames are individually examined(More)