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Viral transcripts, particularly those of the regulatory genes (e.g., rev) in lymphocytic cells chronically infected with human immunodeficiency virus type 2, consist of two types, differing in the structure of the leader sequence derived from the 5' long terminal repeat (LTR). Some transcripts undergo a specific splicing event within the 5' LTR, removing an… (More)
Cytopenia after high-dose chemotherapy and autologous stem cell reinfusion is a major cause of morbidity. Ex vivo cultured expansion and differentiation of CD34+ peripheral blood progenitor cells (PBPC) to neutrophil precursors may shorten the neutropenic period further. We explored the use of these ex vivo cultured PBPCs in nine patients with metastatic… (More)
Markets for domestic housing in countries like England differ from other markets because the stock is fixed in the short term, buyers need to raise mortgages to finance their purchases and prices tend to be set through intermediaries ('es-tate agents' or realtors). We introduce an agent-based model in which some of the main features of the English market… (More)
In this report, we describe the preliminary results from a feasibility and safety study on the clinical use of CD34-positive cells cultured from mobilized peripheral blood. Separation and cell expansion were successfully performed, and the patients tolerated the infusions without problems and achieved engraftment.