Paul A. Peters

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BACKGROUND Few cohort studies have evaluated the risk of mortality associated with long-term exposure to fine particulate matter [≤ 2.5 μm in aerodynamic diameter (PM(2.5))]. This is the first national-level cohort study to investigate these risks in Canada. OBJECTIVE We investigated the association between long-term exposure to ambient PM(2.5) and(More)
Pleural tuberculosis (TB) was employed as a model to study T cell apoptosis at sites of active Mycobacterium tuberculosis (MTB) infection in human immunodeficiency virus (HIV)-coinfected (HIV/TB) patients and patients infected with TB alone. Apoptosis in blood and in pleural fluid mononuclear cells and cytokine immunoreactivities in plasma and in pleural(More)
Tuberculosis (TB) enhances HIV-1 replication and the progression to AIDS in dually infected patients. We employed pleural TB as a model to understand the interaction of the host with HIV-1 during active TB, at sites of Mycobacterium tuberculosis (MTB) infection. HIV-1 replication was enhanced both in the cellular (pleural compared with blood mononuclear(More)
Immunological and clinical profiles were evaluated in 2 groups: human immunodeficiency virus (HIV)-uninfected and HIV-infected patients, with newly diagnosed pulmonary tuberculosis (TB), and tuberculin-skin-test-reactive healthy control subjects. HIV-uninfected patients with TB were also followed up longitudinally during and after chemotherapy. At the time(More)
A new means of quantifying schistosome eggs has been adapted from the laboratory to the field. Urine from 510 individuals in areas of Kenya with a high prevalence of schistosomiasis haematobia was injected in aliquots of 10, 5 and 1 ml on to transparent Nuclepore filters, 13 mm in diameter. The filters were placed face down on glass slides and were read(More)
A double-blind placebo-controlled study of the concurrent administration of albendazole and praziquantel was conducted in>1500 children with high prevalences of geohelminths and schistosomiasis. The study sites were in China and the Philippines, including 2 strains of Schistosoma japonicum, and 2 different regions of Kenya, 1 each with endemic Schistosoma(More)
BACKGROUND Few studies examining the associations between long-term exposure to ambient air pollution and mortality have considered multiple pollutants when assessing changes in exposure due to residential mobility during follow-up. OBJECTIVE We investigated associations between cause-specific mortality and ambient concentrations of fine particulate(More)
BACKGROUND Numerous studies have examined associations between air pollution and pregnancy outcomes, but most have been restricted to urban populations living near monitors. OBJECTIVES We examined the association between pregnancy outcomes and fine particulate matter in a large national study including urban and rural areas. METHODS Analyses were based(More)
OBJECTIVE To describe community-driven alcohol policy for 78, primarily First Nations, Métis and Inuit, communities in Canada's three northern territories (Yukon, Northwest Territories and Nunavut) between 1970 and 2008. This is a first step to understanding the policy-oriented prevention system that has evolved in these areas over time. METHODS(More)