Paul A. Johnston

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The development of preclinical models amenable to live animal bioactive compound screening is an attractive approach to discovering effective pharmacological therapies for disorders caused by misfolded and aggregation-prone proteins. In general, however, live animal drug screening is labor and resource intensive, and has been hampered by the lack of robust(More)
A resistance gene (Rph22) to barley leaf rust caused by Puccinia hordei was introgressed from the non-host species Hordeum bulbosum into cultivated barley. The H. bulbosum introgression in line ‘182Q20’ was located to chromosome 2HL using genomic in situ hybridisation (GISH). Using molecular markers it was shown to cover approximately 20 % of the genetic(More)
The resistance genes Rph22 and Rym16 Hb transferred into barley from Hordeum bulbosum have been separated from a large yield penalty locus that was present in the original introgression line ‘182Q20’. The Hordeum bulbosum introgression line ‘182Q20’ possesses resistance to barley leaf rust (Rph22) and Barley mild mosaic virus (Rym16 Hb ) located on(More)
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