Paul A. Farrell

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During dynamic exercise in warm environments, the requisite increase in skin blood flow (SkBF) is supported by an increase in cardiac output (Qc) and decreases in splanchnic (SBF) and renal blood flows (RBF). To examine interactions between age and fitness in determining this integrated response, 24 men, i.e., 6 younger fit (YF), 6 younger sedentary (YS), 6(More)
In this paper a singularly perturbed reaction-diffusion equation with a discontinuous source term is examined. A numerical method is constructed for this problem which involves an appropriate piecewise-uniform mesh. The method is shown to be uniformly convergent with respect to the singular perturbation parameter. Numerical results are presented which(More)
Physiological stress associated with muscle damage results in systemic insulin resistance. However, the mechanisms responsible for the insulin resistance are not known; therefore, the present study was conducted to elucidate the molecular mechanisms associated with insulin resistance after muscle damage. Muscle biopsies were obtained before (base) and at 1(More)
We performed euglycemic hyperinsulinemic glucose clamps at insulin infusion rates of 1.9, 4.0, 9.3, and 19.3 mU.kg-1 x min-1 in rats with varying severities of iron deficiency anemia (IDA; mean hemoglobin concentrations of 59, 79, 107, and 137 g/l) to assess the effect of IDA on insulin sensitivity and responsiveness. Glucose appearance and disappearance(More)
Iron deficient (ID) and control (C) rats were studied to determine if severe iron deficiency alters insulin-stimulated glucose disposal. Euglycemic hyperinsulinemic glucose clamps were conducted by infusing insulin (2 m mu.kg-1.min-1, constant rate) for 120 min while maintaining euglycemia. In a 12-h fasted state, ID rats were hyperglycemic (109.4 +/- 4.0(More)
In his series of three papers we study singularly perturbed (SP) boundary value problems for equations of elliptic and parabolic type. For small values of the perturbation parameter parabolic boundary and interior layers appear in these problems. If classical discretisation methods are used, the solution of the nite di erence scheme and the approximation of(More)
The temporal pattern for changes in rates of protein synthesis and glucose uptake after resistance exercise, especially relative to each other, is not known. Male Sprague-Dawley rats performed acute resistance exercise (n = 7) or remained sedentary (n = 7 per group), and the following were assessed in vivo 1, 3, 6, 12 and 24 h later: rates of protein(More)
The effect of 12 weeks of resistance training (RT) with or without chromium picolinate (Cr-pic) supplementation on glucose tolerance was assessed in moderately overweight older men and women (age, 62 +/- 4 years; body mass index [BMI], 29.1 +/- 2.5 kg/m2). Seventeen men and 15 women were randomized to groups that consumed either 17.8 micromol chromium per(More)
This study investigated whether insulin has a modulatory effect on protein synthesis rates in skeletal muscle after four sessions of resistance exercise. Male rats engaged in resistance exercise (Acute) that required full extension of the hindlimbs with weights over the scapula or performed the standing movement with no additional weight (Nonex). Two(More)
This study had the following objectives: 1) to determine whether diabetic rats could increase muscle mass due to a physiological manipulation (chronic resistance exercise), 2) to determine whether exercise training status modifies the effect of the last bout of exercise on elevations in rates of protein synthesis, and 3) to determine whether chronic(More)